Trial | NCT04050267  Report issue

Title

Effects of Low Concentrations of Nitrous Oxide
Effects of Low Concentrations of Nitrous Oxide on Cognitive Functions and Reaction Time

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    16
The aim of the study is to test the effects of low concentrations of nitrous oxide on cognitive functions and reaction time in human.
Nitrous oxide is a widely used gas in medicine, in standard concentrations above 50%. Its favourable physical properties and easy detectability by anaesthetic gas analysors predispose nitrous oxide to become a possible "tracing gas" for leak detection in experiments in which modified breathing system are in use. In these breathing experiments, the inspired concentrations of nitrous oxide would be well below the anaesthetic/analgesic concentrations. The aim of this study is to investigate the effects of these low concentrations of nitrous oxide (5, 7, 10, 12, 15, 20 %), compared to placebo (air, 0% nitrous oxide). The cognitive functions are tested using Digit Symbol Substitution Test, Reaction Time and Visual Analogue Scale.
Study Started
Apr 25
2019
Primary Completion
Apr 29
2019
Study Completion
Apr 29
2019
Last Update
Aug 09
2019

Drug Nitrous Oxide

Breathing nitrous oxide, concentrations 5, 7, 10, 12, 15, 20 % in air with 21 % oxygen, in random order.

Other Placebo - air

Breathing air with 21 % oxygen, no nitrous oxide.

Control group - air Placebo Comparator

Breathing air with 21 % of oxygen (0% nitrous oxide). Performing cognitive tests as per protocol.

Intervention Group - 5% nitrous oxide Experimental

Breathing 5% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Intervention Group - 7% nitrous oxide Experimental

Breathing 7% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Intervention Group - 10% nitrous oxide Experimental

Breathing 10% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Intervention Group - 12% nitrous oxide Experimental

Breathing 12% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Intervention Group - 15% nitrous oxide Experimental

Breathing 15% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Intervention Group - 20% nitrous oxide Experimental

Breathing 20% nitrous oxide in air with 21 % of oxygen. Performing cognitive tests as per protocol.

Criteria 

Inclusion Criteria:

healthy volunteers from the Czech Technical University

Exclusion Criteria:

pregnancy
allergy to nitrous oxide
severe asthma or other severe respiratory conditions
severe cardiovascular conditions
No Results Posted