Trial | NCT04021342  Report issue

Title

The Effect of Tart Cherry (Prunus Cerasus) Concentrate on Physiological and Cognitive Function
The Effect of Tart Cherry (Prunus Cerasus) Concentrate on Cardiometabolic Risk Factors, Exercise Capacity and Cognitive Function

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    56
A randomized, double blind, counterbalanced, placebo controlled independent groups design to determine the effects of 3 month supplementation with tart cherry concentrate on indices of cardiometabolic health, exercise capacity and cognitive function. Following screening and recruitment, participants are familiarised with the testing equipment and procedures after which they will be randomly assigned to receive either Montmorency tart cherry concentrate (MC) or an isocaloric placebo (PLA), stratified by gender. The study is comprised of two experimental visits and outcome variables are assessed at baseline (before supplementation) and at 3 months (follow up; after supplementation).
Study Started
Oct 12
2018
Primary Completion
Nov 29
2019
Study Completion
Feb 29
2020
Last Update
Apr 08
2021

Dietary Supplement Montmorency tart cherry concentrate

Based on previous analysis done by our laboratory each 60 ml of Montmorency tart cherry concentrate contains approximately 73.5 mg of anthocyanins (cyanidin-3-glucoside equivalents) and 178.8 mg of total phenolics (mean gallic acid equivalents)

Dietary Supplement Placebo

Placebo beverage matched for calorie content and visual properties of the cherry concentrate

Montmorency tart cherry concentrate Active Comparator

Participants will consume 30 ml of Montmorency tart cherry concentrate (MC) concentrate (King Orchard farms, USA) twice daily, once in the morning and again in the evening. According to the manufacturer each 30 ml dose of MC is estimated to be equivalent to approximately 90 whole cherries (equating to ~180 cherries per day).

Isocaloric cherry flavoured placebo Placebo Comparator

The PLA is prepared by mixing by mixing unsweetened black cherry flavoured Kool-Aid (Kraft Foods, United States), dextrose, fructose with water to best match the calorie content of the MC concentrate. Additional lemon juice, for tartness, and artificial food colouring is added so the final product had a similar visual properties to the active comparator.

Criteria 

Inclusion Criteria:

Healthy individuals between the ages of 40-60 years
consume on average ≤5 servings of fruits and vegetables per day
additionally have ≥1 risk factor for type 2 diabetes

Exclusion Criteria:

not regularly taking medication (or stabilised ≥ 3 months, with no adverse symptoms) or antioxidant supplements
history of cardiometabolic, gastointestinal disease or malabsorption syndromes
stage 2 hypertension (SBP >159 mm Hg or DBP >99 mm Hg)
individuals who report changes in dietary or physical activity patterns within 3 months
vegetarians, vegans or known eating disorders
alcohol intake of more than 21 units per week
BMI ≥40 kg/m2
are pregnant or planning to become pregnant during the study, lactating, or initiating or changing a hormone replacement therapy regimen within 3 months of the start of the study
No Results Posted