Trial | NCT03830970  Report issue

Official Title

Effect of Canned Beans of Multiple Varieties in Daily Amounts of 1 Cup and 1/2 Cup on Serum LDL Cholesterol and Other Cardiovascular Disease Risk Biomarkers in Adults With Elevated LDL Cholesterol

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    White Rice ...

  • Study Participants

    73
The Bean Study will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol.
The Bean Study (TBS) is a a multi-centre, randomized, crossover design study which will examine the effects of consuming two daily amounts of canned beans of multiple varieties on fasting serum cholesterol profile in adults with elevated LDL cholesterol. Participants will consume daily amounts of 1 cup canned beans, ½ cup of canned beans and 1 cup of white rice for 4 weeks each, separated by minimum 4-week washout periods. At the start and end of each 4-week treatment period, fasting blood samples will be collected and analyzed for lipids, glucose insulin and short chain fatty acids (SCFAs). Fecal samples will also be collected and analyzed for SCFA, bile acids and gut microbiota. Body weight and BMI will be also be measured at the start and end as well as mid-way of each treatment period. Finally 3-day food records will be completed mid-way during each treatment period.
Study Started
Mar 05
2019
Primary Completion
Jan 05
2021
Study Completion
Jan 05
2021
Last Update
Aug 05
2021

Dietary Supplement Canned beans of multiple varieties

Daily rotation of different varieties of canned beans including black, navy, pinto, red kidney and white kidney

Dietary Supplement White Rice

Minute Rice Long Grain White Rice

1 cup of canned beans of multiple varieties Experimental

Consumption of 1 cup of canned beans of multiple varieties each day for 4 weeks

1/2 cup of canned beans of multiple varieties Experimental

Consumption of 1/2 cup of canned beans of multiple varieties each day for 4 weeks

1 cup of White rice Other

Consumption of 1 cup of white rice each day for 4 weeks

Criteria 

Inclusion Criteria:

Male and female adults (≥18 years)
BMI 18.5-35 kg/m2
LDL cholesterol 3.0-5.0 mmol/L

Exclusion Criteria:

Triglycerides ≥3.0 mmol/L
Diabetes (fasting blood glucose ≥7.0 mmol/L)
Blood pressure >140/90 mmHg
Major medical conditions
Medical or surgical events requiring hospitalization within the last 3 months
Medication use that would interfere with the study outcomes (e.g. cholesterol-lowering medications, diabetes-related medications, steroids). All other medications are okay if at a stable (3-month) dose
Antibiotic use within the last 3 months
Tobacco product use (>5 times per week)
Cannabis use during the study
Probiotic supplement use (could do a 1-month washout before study)
Dietary fibre supplement use (could do a 1-month washout before study)
NHPs used for cholesterol lowering or glycemic control. All other NHPs are okay if at a stable (3-month) dose.
Pulse consumption >4 servings per week
Food allergy or non-food life-threatening allergy
Pregnant or breastfeeding
Alcohol consumption (>14 drinks/week or >4 drinks/sitting)
Recent or intended significant weight loss or gain (>4 kg in previous 3 months)
National-level or professional athlete
Overnight shift worker
No Results Posted