Trial | NCT03789708  Report issue

Title

Effects of Gum Arabic Supplementation in Hemodialysis Patients
Study of Some Pharmacological and Biochemical Effects of Gum Arabic Supplementation to Hemodilaysis Patients

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    80
Gum Arabic is a naturally produced gummy exudate from Acacia Senegal tree. It's a complex polysaccharide with proven prebiotic properties. Through its effect on intestinal bacteria, it's expected to reduce systemic levels of toxic bacterial metabolites and reduce inflammatory markers.By increasing fecal bacteria mass it's also expected to reduce blood urea level. These changes are potentially beneficial to hemodialysis patients who suffer from disturbed intestinal flora and a chronic inflammatory status. The investigators hypothesize that supplementing the diet of hemodialysis patients with Gum Arabic for four weeks would reduce inflammatory markers, increase total anti-oxidant capacity and reduce blood urea concentration.
Study Started
Nov 01
2018
Primary Completion
Mar 01
2019
Anticipated
Study Completion
Jun 01
2019
Anticipated
Last Update
Jan 03
2019

Dietary Supplement Gum Arabic

Instantly soluble granules of Gum Arabic; 100% Acacia Senegal

Other Placebo

Maltodextrin powder, easily soluble

A Experimental

Patients will receive 10 g of Gum Arabic supplementation daily for four weeks. Gum Arabic is provided in the form of easily soluble granules. Participants are asked to dissolve it in water or juice and drink it.

B Placebo Comparator

Patients will receive 5 g of maltodextrin supplementation daily for four weeks. Maltodextrin is an easily digested polysacharide provided in the form of soluble whitish powder that has no taste or odor. Participants are asked to dissolve it in water or juice and drink it.

C Experimental

Patients will receive 20 g of Gum Arabic supplementation daily for four weeks

D Experimental

Patients will receive 40 g of Gum Arabic supplementation daily for four weeks

Criteria 

Inclusion Criteria:

Adult end-stage renal disease patients maintained on regular hemodialysis

Exclusion Criteria:

Chronic liver disease
Malignant condition
Inflammatory bowel disease
History of bowel resection
Long term antibiotic therapy
Pregnancy or lactation
Current use of immunosuppressive medication
No Results Posted