Trial | NCT03779516  Report issue

Title

Effect of Nebulized Lidocaine on Postoperative Sore Throat
Effect of Preoperative Nebulized Lidocaine on Postoperative Sore Throat After Endotracheal Intubation

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Terminated

  • Intervention/Treatment

    Lidocaine ...

  • Study Participants

    110
The purpose of this study is to test the hypothesis that use of preoperative nebulized lidocaine is reduced the incidence of postoperative sore throat after endotracheal intubation.
Adult patients undergoing video-assisted thoracic surgery (VATS) requiring double lumen tube (DLT) endotracheal intubation for one-lung ventilation (OLV) were enrolled in the study. Patients were randomized by means of computer-generated order randomization into two groups: Group C (those who received a saline solution as placebo delivered by nebulization) and Group L (those who received lidocaine delivered by nebulization).

At 1, 6 and 24 h after tracheal extubation, an observer blinded to treatments evaluated the patients in terms of sore throat and hoarseness. In addition, Patients' satisfaction, intraoperative and postoperative opioid and analgesics consumption and complaints such as dysphagia, nausea and vomiting were recorded. Hemodynamic variables such as blood pressure and heart rate were also recorded.
Study Started
Dec 19
2018
Primary Completion
Apr 22
2019
Study Completion
Jul 15
2019
Last Update
Apr 30
2020

Other Saline

Effect of saline on postoperative sore throat

Other Lidocaine

Effect of nebulized lidocaine on postoperative sore throat

Group C Active Comparator

In Control Group, 4 mL of saline solution was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min

Group L Active Comparator

In Lidocaine Group 4 mL of 4% lidocaine was administered using a face mask and a compressed gas-powered jet nebulizer for 15 min

Criteria 

Inclusion Criteria:

patients undergoing video-assisted thoracic surgery requiring double lumen tube endotracheal intubation for one-lung ventilation
American Society of Anesthesiologists class 1,2 and 3
Ability to consent

Exclusion Criteria:

patients <18 years old
body mass index (BMI) <20 or >35 kg/m2
Mallampati grade 3 or 4
mouth opening < 3 cm
preexisting hoarseness or sore throat
coagulopathy
patient with upper respiratory tract infection
No Results Posted