Trial | NCT03716960  Report issue

Title

The Effects of Pumpkin Seed Oil Supplementation on Cardiovascular Function in Postmenopausal Women.
The Effects of Pumpkin Seed Oil Supplementation on Vascular Hemodynamics, Stiffness and Cardiac Autonomic Function in Postmenopausal Women.

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    23
Postmenopausal women have a higher prevalence of cardiovascular (CV) disease than age-match men. Growing evidence from rat studies have demonstrated CV-protective effects of pumpkin seed oil (PSO).

The investigators hypothesis is that PSO would improve CV health in postmenopausal women.
The purpose of the study is to examine the effects of 6 weeks of PSO on arterial and autonomic function in postmenopausal women. Specific aims of the study are to:

To investigate the extent to which PSO will improve cardiovascular disease risk factors by assessing arterial stiffness, aortic BP and wave reflection, and autonomic function (heart rate variability).
Study Started
Sep 01
2017
Primary Completion
Jun 30
2018
Study Completion
Jun 30
2018
Last Update
Oct 24
2018

Other Pumpkin Seed Oil

This intervention consisted of 6 weeks of PSO consumption. Subject were supplemented with 3 g/day of PSO which was ingested in the form of 1g capsules with each main meal of the day (breakfast, lunch and dinner).

Other Placebo

This intervention consisted of 6 weeks of placebo consumption. Subject consumed 1 capsule of maltodextrin with each main meal of the day to match the dose and number of capsules ingested daily by the PSO group.

Pumpkin Seed Oil Experimental

This arm involved 6 weeks of PSO consumption. Subject were supplemented with 3 g/day of PSO which was ingested in the form of 1g capsules with each main meal of the day (breakfast, lunch and dinner). Likewise,

Placebo Placebo Comparator

This arm involved 6 weeks of placebo consumption. Subject consumed 1 capsule of maltodextrin with each main meal of the day to match the dose and number of capsules ingested daily by the PSO group.

Criteria 

Inclusion Criteria:

Female
45 to 65 years of age
At least 1 year after menopause
BMI <39.9
Sedentary or low active (less than 2 hr per wk)

Exclusion Criteria:

known heart disease
peripheral vascular disease
diabetes, body mass index
BMI> 40 kg/m2
other chronic diseases
taking medications (e.g., hormone replacement therapy, beta blockers, calcium channel blockers, antidepressants and stimulants) that could affect the outcome variables
smokers
history of steady exercise or received exercise training and dietary changes in the last year
No Results Posted