Trial | NCT03625960  Report issue

Title

Cantharone for the Treatment of Perenial Warts
Trichloroacetic Acid Versus Cantharone for the Treatment of Perenial Warts

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    12
Comparison of trichloroacetic acid versus cantharidine for the treatment of perenial warts.
Warts are one of the most common sexually transmitted diseases. They are caused by the human papilloma virus (HPV) that causes cervical cancer. Warts can grow, obstruct labor, and spread. Patients presenting to the obgyn clinic with perenial warts were randomized to treatment with trichloroacetic acid (one of the many types of treatments) or to the treatment with cantharidine group. Cantharidine is a vesicant extracted from beetle bugs which painlessly causes a small blister to form and cures the patient from the HPV infection causing the wart . We compared cosmesis, scar formation, pain and number of treatments (visits) as well as effectiveness in both groups.

Objectives

Determine if cantharone is more effective than trichloroacetic acid (TCA) for removal of warts
Compare pain levels (pain during application) for each method
Compare patient satisfaction for each method
Compare scar formation and cosmesis for each method
Study Started
Jun 15
2006
Primary Completion
Jun 15
2007
Study Completion
Jul 15
2007
Last Update
Aug 10
2018

Drug Cantharidin

A thin film of cantharidin is applied to the surface of the wart and to 1 millimeter area surrounding the wart. After the film dries, it is covered with an occlusive dressing for 24 hours. The patient removes the area the next day and thoroughly washes the area with soap and water. Patients return to clinic a week later.

Drug Trichloroacetic Acid

Trichloroacetic acid is applied to the surface of the wart with a wooden applicator and after drying the area is washed with soap and water in an hour.

Cantharidine group Experimental

Application of cantharidine to perenial warts

trichloroacetic acid group Active Comparator

application of trichloroacetic acid to perenial warts

Criteria 

Inclusion Criteria:

Warts on the perenial area
Less than 4mm across.

Exclusion Criteria:

Pregnancy
Less than 18 years old
Lesions larger than 4 millimeters across
Unclear diagnosis
Internal warts
Diabetes
HIV
Warts within 2 cm of mucosal areas
No Results Posted