Trial | NCT03615885  Report issue

Title

Acute Cardio-metabolic Responses to Montmorency Tart Cherry Supplementation in Metabolic Syndrome Patients
Acute Cardio-metabolic Responses to Different Forms of Montmorency Tart Cherry Supplementation in Humans With Metabolic Syndrome

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    11
The present study examined the effect of Montmorency tart cherry juice and capsules on functional and blood-based cardio-metabolic markers in humans with Metabolic Syndrome. Participants received a single bolus of Montmorency tart cherry juice, Montmorency tart cherry capsules and placebo in a random, crossover trial. Outcome variables were measured immediately pre- and up to 5 hours post-bolus. It was hypothesised that Montmorency tart cherry juice and capsules would improve cardio-metabolic markers. Furthermore, it was hypothesised that Montmorency tart cherry capsules would be more beneficial than Montmorency tart cherry juice due to increased bioavailability of phytochemicals.
Study Started
Jun 06
2017
Primary Completion
Oct 15
2017
Study Completion
Dec 01
2017
Last Update
Aug 06
2018

Dietary Supplement Montmorency Tart Cherry Capsules

Capsules are made from 100% natural, tart Montmorency cherries. Carefully prepared Montmorency cherry skins are freeze-dried and milled into a fine powder to protect the cherry phytonutrients and optimise absorbtion. This powder is then encapsulated into a 100% vegetarian shell.

Dietary Supplement Montmorency Tart Cherry Juice

100% natural, tart Montmorency cherry concentrate (30mL) diluted with 100mL water. Concentrate contains no sweeteners, preservatives, flavourings or added sugar.

Dietary Supplement Placebo

130ml serving Placebo composition: Water (100ml), Cherry Cordial Concentrate (30ml), Citric Acid (1.5g), Maltodextrin (24.75g), Black Food Colouring (2ml).

Placebo Drink Placebo Comparator

Placebo drink attempted to match for total energy, appearance and taste of Montmorency tart cherry juice.

Montmorency Tart Cherry Capsules Experimental

10 capsules consumed to match total anthocyanin content to Montmorency tart cherry juice.

Montmorency Tart Cherry Juice Experimental

Single-bolus of Montmorency tart cherry juice (130 mL)

Criteria 

Inclusion Criteria:

Non-smoker,

Meet 3 of 5 criteria for Metabolic Syndrome based on National Cholesterol Education Program-Adult Treatment Panel III guidelines:

Waist Circumference: >102cm (men), >88cm (women)
Fasting Serum Triglycerides: ≥1.69 mmol.L-1
Fasting High Density Lipoprotein: <1.03 mmol.L-1 (men), <1.29 mmol.L-1 (women)
Blood Pressure: ≥130 mmHg SBP or ≥85 mmHg DBP
Fasting Plasma Glucose: ≥6.1 mmol.L-1

Exclusion Criteria:

Current or previous history of gastrointestinal, cardiovascular, hepatic or renal disease, currently diagnosed with diabetes or uncontrolled hypertension (≥160/100 mmHg), allergy to maltodextrin or specific fruit products and those currently taking medication (such as steroids, NSAIDs, antibiotics, antihypertensive, hypoglycaemic, lipid-lowering drugs) or currently using any nutritional or antioxidant supplement. Heavy alcohol consumption (>14 units per week).
No Results Posted