Trial | NCT03577223  Report issue

Official Title

Egg Effects on the Immunomodulatory Properties of HDL

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    Whole Eggs ...

  • Study Participants

    28
The purpose of this study is to investigate the effects of egg intake on markers of HDL function and immune inflammation in healthy adults.
28 healthy men and women (age 18-35 years old) will be recruited to participate in a 16-week randomized crossover study. Upon enrollment, all subjects will enter a 4-week run-in egg-free period where they will refrain from consuming any egg-based foods (Period 1). Subjects will then enter the first intervention period, where they be randomly assigned to consume either 3 whole eggs/day or the equivalent amount of egg white-based egg substitute/day for 4 weeks (Period 2). Afterwards, subjects will enter a 4-week washout period where egg-based foods are restricted (Period 3), followed by a second intervention period, where they be assigned to the alternative whole egg- or egg white-based treatment for 4 weeks (Period 4). Subjects will come to the Department of Biology at Fairfield University every two weeks to check-in, and to pick up their egg products during the intervention periods. Subjects will be asked to maintain their normal diet and physical activity practices throughout all periods of the study. Subjects will complete 5-day dietary records and physical activity logs at the end of each study period.
Study Started
Sep 07
2018
Primary Completion
May 15
2019
Study Completion
May 15
2019
Last Update
May 28
2021

Other Whole Eggs

3 whole eggs per day for 4 weeks

Other Egg White-Based Egg Substitute

3-egg equivalent of egg white-based egg substitute per day for 4 weeks

Whole Eggs Experimental

Egg White-Based Egg Substitute Active Comparator

Criteria 

Inclusion Criteria:

18-35 years old
Body mass index (BMI) < 30 kg/m2, or < 30% body fat for men and < 40% body fat for women
Willingness to consume eggs or egg whites on a daily basis during study periods

Exclusion Criteria:

< 18 years old; > 35 years old
BMI ≥ 30 kg/m2, or ≥ 30% body fat for men and ≥ 40% body fat for women
Self-reported history of diabetes mellitus, coronary heart disease, stroke, renal problems, liver disease, cancer, pregnancy or lactation, autoimmunity, chronic infections, or egg allergy
Taking lipid-lowering medications (e.g. statins, fibrates)
A preexisting medical condition or implanted medical device that prevents participation in bioelectrical impedance measurements of body composition
Clinical lipid and glucose values that are highly elevated, including fasting triglycerides levels higher than 500 mg/dL, fasting glucose higher than 126 mg/dL, and plasma total cholesterol greater than 240 mg/dL
No Results Posted