Trial | NCT03401177  Report issue

Title

Treatment of Early Phase Achilles Tendinopathy - the Effect of NSAIDs
The Effect of NSAIDs in the Early Phase of Achilles Tendinopathy

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    Naproxen 500 Mg ...

  • Study Participants

    70
this study evaluates the addition of initial short term NSAID treatment to physiotherapy prescribed exercise treatment in patient with early phase tendinopathy. Half of the participants will initially receive NSAID (naproxen) for 7 days, while the other half will receive a placebo, where after both groups will be subjected to 3 months heavy slow resistance training.
NSAID is effective in short term pain relief in musculoskeletal disorders, but little is known about the long-term effect in early phase tendinopathy, when used as a supplement to treatment as usual, namely heavy slow resistance training and training load reduction. In this study, NSAIDs will be used, which works through COX inhibition, which again inhibits Prostaglandins, in this way investigators attempt to dampen the initial inflammation and pronounced cell activity that is thought to be present in early phase tendinopathy. With this project, it will be attempted to investigate whether initial dampening adds to the effect achieved through heavy load resistance training, which is thought to stimulate structural repair and regeneration in the tendon, by applying appropriate load to the tendon tissue, thereby stimulating the tendon cells to repair and regeneration.
Study Started
Jan 15
2018
Primary Completion
Jul 31
2019
Study Completion
Apr 27
2020
Last Update
Jul 09
2020

Drug Naproxen 500 Mg

Naproxen is used as a tool to dampen the inflammation thought to be present in early phase Tendinopathy

  • Other names: Naproxen-E Mylan

Drug Placebo Oral Tablet

Placebo is used, to provide a control to the active group.

  • Other names: Placebo

Other Heavy resistance training

Heavy slow resistance training - used in both groups subsequent to the initial week of NSAID or placebo treatment.

  • Other names: HRT

Naproxen & Heavy resistance training Experimental

Naproxen: 500 mg x 2 daily for 7 days, HRT: 3 months physiotherapy guided training.

Placebo & Heavy resistance training Placebo Comparator

Placebo oral tablet: pill manufactured to mimic naproxen tablet x 2 daily for 7 days, HRT: 3 months physiotherapy guided training.

Criteria 

Inclusion Criteria:

Activity related pain in the achilles tendon
Palpation pain in the achilles tendon
Onset of symptoms within the last 3 months

Exclusion Criteria:

Previous injury in the achilles tendon on the ipsilateral side.
Recent infection around the achilles tendon
Previous surgery in the achilles tendon.
Contraindications for NSAID treatment.
NSAID treatment for the current injury
Medication with NSAID interaction
No Results Posted