Trial | NCT03361618  Report issue

Title

Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway
Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway in Spermatozoa and Seminal Plasma of Iraqi Asthenospermic Patients

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    120
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia treatments, such as given an oral zinc supplementation, on the activity of urate-related enzymes, which are important in fertility of human.
The present study was designed to investigate the effect of zinc supplementation on the qualitative and quantitative characteristics of semen, along with uric acid levels and urate-related enzymes in the seminal plasma and spermatozoa of asthenospermic males.
Study Started
Jul 01
2011
Primary Completion
Jun 01
2012
Study Completion
Jun 01
2012
Last Update
Dec 05
2017

Dietary Supplement Zinc Sulfate

The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Zinc sulfate Experimental

60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).

Healthy control No Intervention

60 fertile (age 31.6±3.3 year) men, no treatment.

Criteria 

Inclusion Criteria:

The presence of asthenozoospermia in the semen sample.
Must be unable to reproduce.

Exclusion Criteria:

the absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
No Results Posted