Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Female 35-65 years of age
Post-menopausal (greater than 1 year since last menses)
Healthy as determined by blood chemistry, hematology, urinalysis and past medical history
BMI 18-27.5 kg/m2
Normal blood magnesium between 0.65 and 1.05mmol/L
Normal urinary creatinine clearance 1.18 - 2.18mL/s
Non-smoker or ex-smoker for greater than 6 months
Agrees to maintain current dietary and physical activity habits for the duration of the study period except as instructed during run-in periods and on test days
Willing and able to provide voluntary, written, informed consent

Exclusion Criteria:

Woman who is peri-menopausal, premenopausal, pregnant, breastfeeding, or planning to become pregnant during the course of the trial
Significant cardiac history defined as a history of myocardial infarction (MI); coronary angioplasty or bypass graft(s); valvular disease or repair; unstable angina pectoris; trans ischemic attack (TIA); cerebrovascular accidents (CVA); congestive heart failure; or coronary artery disease (CAD)
Uncontrolled hypertension defined as untreated systolic blood pressure > 160 mmHg and/or diastolic blood pressure > 100 mmHg
Uncontrolled diabetes defined as fasting blood glucose > 7 mmol/L
Treated or untreated thyroid disorders
History of renal and/or liver disease
History of clinically significant gastrointestinal pathology (e.g. chronic diarrhea, inflammatory bowel disease) unresolved gastrointestinal symptoms (e. g. diarrhea, vomiting) or other diseases known to interfere with absorption, distribution, metabolism or excretion of the IP or comparators
History of (in previous 5 years), or currently being treated for cancer (excluding basal cell skin carcinoma)
Unstable psychiatric disorder
Acute illness, as judged by the Investigator, within 2 weeks of the first treatment period (Visit 3a)
Immunocompromised individuals such as participants that have undergone organ transplantation or participants diagnosed with human immunodeficiency virus (HIV)
History of hemoglobinopathies such as sickle cell anemia or thalassemia, sideroblastic anemia
Significant abnormal liver function as defined as AST and/or ALT > 2x the upper limit of normal (ULN), and/or bilirubin > 2 x the ULN
Serum creatinine > 95 umol/L
Anemia of any etiology defined as hemoglobin < 110 g/L for females
Use of anticoagulants, statins, or any other medication for the treatment of hypercholesterolemia and/or hypertension
Use of prescribed medication or over the counter supplements for weight loss
Use of acute medication, including antacids, within 72 hours of study supplement dose
Use of over the counter or prescription products containing magnesium and/or calcium (e.g. multivitamins, calcium carbonate, etc.) within 2 weeks of screening (Visit 1a)
Use of medications known to interact or interfere with magnesium absorption (See section 3.8.2)
Use of nicotine-containing products in any form (eg, chewing tobacco, gum, patch) within 30 days of the first test period (Visit 3a)
Use of caffeine supplements
Consumption of more than 50g of chocolate per day
Excessive consumption of caffeinated beverages (e.g. >2 cups of any combination of tea, coffee, energy drinks, caffeinated soda, etc. per day) or participants who experience caffeine withdrawal headaches
Allergy or sensitivity to study supplement ingredients
Food allergies or sensitivities to any of the foods outlined in Appendix 2.
Vegan or vegetarian
Recent change in weight (up or down more than 10 % of usual body weight, within the past year)
Participants who work, evening or night shifts
Donation or loss of whole blood prior to the administration of the study product as follows: 50-300 mL of whole blood within 30 days, 301-500 mL of whole blood within 45 days or more than 500 mL within 56 days prior to the administration of the IP or comparators
Presence or history (past 6 months) of alcohol or drug abuse; alcohol use of >2 standard alcoholic drinks per day
Participant is unwilling or unable to abide by the requirements of the protocol
Any condition that would interfere with the participant's ability to comply with study instructions, might confound the interpretation of the study, or put the participant at risk
Participant has taken an investigational medicine or has participated in a research study within 30 days prior to the run-in period (Visit 2a)