Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Able to give informed consent prior to study
Male or Female with Diagnostic Criteria of Parkinson's disease
Age 35 to 85 years old
Parkinson's disease not due to trauma, infection, brain tumor, cerebrovascular disease
Hoehn and Yahr Stage III or IV

Parkinson's disease observed in the absence of:

Oculomotor palsy
Cerebellar sign
Orthostatic hypotension (drop greater than 20mmHg in mean pressure)
Pyramidal sign
Amyotrophy
Good general health or stable medical condition well controlled, without contraindications to anesthesia

Exclusion Criteria:

Patients with severe dementia and brain atrophy on MRI
Patients with severe hypertension; renal, liver, cardiac or other major organ disease; coagulopathy; cancer; other significant systemic illnesses; hepatitis, HIV
Patients older than 85 or younger than 35
Patients who withhold informed consent
Patients with a history of alcohol or drug abuse
Sexually active women of childbearing potential without adequate form of birth control
Evidence of abnormal coagulation or anticoagulant therapy
Pregnancy or lactation
History of seizure disorders or current use of antiepileptic medication
Severe cognitive impairment
Clinically significant laboratory abnormality