Trial | NCT03253562  Report issue

Title

Metformin Versus Vildagliptin for Diabetic Hypertensive Patients
Comparative Efficacy and Safety of Vildagliptin Versus Metformin in Reduction of Cardiovascular Complications in Type 2 Diabetic Patients With Hypertension

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    120
This is a controlled study to measure the efficacy of using metformin or vildagliptin for type 2 diabetic patients who suffers from hypertension to reduce cardiovascular risk resulting from both diabetes and hypertension using different parameters measuring
Several studies indicated that type 2 diabetes mellitus and hypertension are associated with increased cardiovascular complications. Recently, studies suggest that metformin and vildagliptin can reduce cardiovascular complications in diabetic patients with unclear mechanisms. This work aimed to determine the effect of metformin and vildagliptin on diabetic-hypertensive patients. Patients were allocated into four groups: groupI: healthy volunteers, groupII: patients recently diagnosed with their hypertension and diabetes, groupIII: patients treated with captopril (25mg once daily) for their hypertension in addition to metformin (1000mg bid) groupIV: patients treated with captopril (25mg bid) for hypertension in addition to vildagliptin (50mg bid). At the end of the therapeutic period, then total cholesterol, LDL,serum Creatinine level, blood pressure and vascular endothelial growth factor (VEGF) levels in serum will be measured for different groups to estimate the benefits of one drug over the other one in protecting against cardiovascular risks for diabetic hypertensive patients..
Study Started
Feb 01
2017
Primary Completion
Aug 01
2017
Study Completion
Aug 01
2017
Last Update
Aug 18
2017

Drug Metformin Pill

a biguanide used as an insulin sensitizer for patients suffering from type 2 diabetes mellitus

Drug Vildagliptin 50 mg

Dpp4i antihyperglycemic drug used for treatment of type 2 diabetes mellitus

Healthy control No Intervention

healthy volunteers not suffering from diabetes or hypertension

diabetic hypertensive recently diagnosed patients No Intervention

recently diagnosed patients suffers from diabetes type 2 and hypertension but didnot receive their proper treatment yet

Metformin treated group Other

diabetic hypertensive patients which were treated with captopril for their hypertension and metformin for their diabetes

Vildagliptin treated group Other

diabetic hypertensive patients which were treated with captopril for their hypertension and vildagliptin for their diabetes

Criteria 

Inclusion Criteria:

Patients suffering from moderate HTN and DM, their HbA1c ≥ 7 and age range between 40-60 years, treatment with diet alone, any combination of oral antidiabetic agents and/or insulin before admission

Exclusion Criteria:

Clinical evidence of ischemic heart disease, chronic obstructive pulmonary disease, presence of diabetic ketoacidosis (DKA), patients admitted to intensive care unit (ICU), subjects expected to undergo surgery during the study period, patients with clinically relevant hepatic disease, impaired renal function (serum creatinine ≥3.0 mg/dL), systemic infections or pregnancy. Also, patients on medications known to interfere with the blood glucose level (either increasing or decreasing) were excluded from the study.
No Results Posted