Trial | NCT03113708  Report issue

Title

The Effect of Heparinization Due to LBW
The Effect of Heparinization Due to LBW in Cardiac Surgery

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    heparin ...

  • Study Participants

    50
High dose heparin regimens are required in cardiac surgery under cardiopulmonary bypass (CPB) and this may increase postoperative bleeding. The aim of this study is to evaluate the effect of heparin dose calculated according to lean body weight on intraoperative and postoperative bleeding.
Patients with preoperative demographic data such as age, gender, body weight, height, and additional disease, medications, previous surgery, preoperative Htc / Hb values were recorded in the operation room without medical premedication. Standard anesthesia induction was performed after arterial cannulation and peripheral venous route. Patients were randomly divided into two groups: 400 IU heparin / kg (Group I) and 400 IU heparin / kg (Group II) according to actual body weight and lean body weight respectively before CPB. Before and after heparin administration, CPB entry and ACT (Activated Clotting Time) values were counted every 30 minutes, after CPB exit and protamine. In both groups, supplemental heparin was administered when there was a failure to reach the pre-CPB target ACT value of 400 sec. Hemodynamic data and transfusion requirements were recorded during the operation. Patient's intraoperative CPB and crossover times, postoperative drainage volume and blood transfusion requirement were recorded.
Study Started
Apr 30
2017
Anticipated
Primary Completion
May 20
2017
Anticipated
Study Completion
Jun 20
2017
Anticipated
Last Update
Apr 14
2017

Drug Heparin Sodium

Heparinisation 2-4 mg/kg will be done according to actual body weight or lean body weight.

Heparinisation,actual body weight Sham Comparator

In 'Heparinisation,actual body weight' group , heparin sodium; will be done according to actual body weight and ACT will be recorded prior to CPB. Before coming out CPB, protamine will be done according to heparin dose. And then ACT will be recorded.

Heparinisation, lean body weight Experimental

In 'Heparinisation, lean body weight' group heparin sodium will be done according to lean body weight and ACT will be recorded prior to CPB. Before coming out CPB, protamine will be done according to heparin dose. And then ACT will be recorded.

Criteria 

Inclusion Criteria:

18-65 years old, first time valve surgeries which was done on-pump.

Exclusion Criteria:

Revision valve surgeries
Patients with coagulation deficits
No Results Posted