Official Title
High Fiber Rye Foods for Weight and Body Fat Reduction
Phase
N/ALead Sponsor
Swedish University of Agricultural SciencesStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Overweight ObesityIntervention/Treatment
Refined wheat ...Study Participants
242The overall aim of this study is to investigate whether a diet rich in rye fiber from wholegrain rye, compared to refined wheat, as part of a hypocaloric diet leads to larger weight loss and lower body fat content after 12 weeks of intervention. Furthermore the study will investigate the effect on appetite as a potential underlying mechanism for differences in weight loss and body fat reduction.
Cereal products based on wholegrain rye
Wholegrain rye products with a high content of dietary fiber
Refined wheat products with a low content of dietary fiber
Inclusion Criteria: BMI 27-35 kg/m2 Hb≥120g/l Serum thyroid stimulating hormone (TSH) ≤4.00 mIU/L Plasma low density lipoprotein cholesterol <5.3 mmol/L Plasma triglycerides ≤1.8 mmol/L Signed informed consent Freezer capacity for 2 weeks bread provision Exclusion Criteria: Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study Unable to complete satisfactorily the 3-day weighted food record at screening visit 2. Unable to lose 0.5 kg or more during the run-in period for men and women not having menstruation during the run in period Increased body weight, despite reported adherence to dietary intake for women with menstruation during the run-in period. Using nicotine products on a daily basis (incl. chewing gum, patches, snus etc.) Using e-cigarettes (regardless of nicotine content) Following any weight reduction program or having followed one during the last 6 months prior to visit 1 Diastolic blood pressure 105 mm Hg at visit 1 Systolic blood pressure 160 mm at visit 1 History of stomach or gastrointestinal conditions (Inflammatory bowel disease, Crohn's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.) More than 10 hours physical activity per week History of heart failure or heart attack within 1 year prior to screening Have type I diabetes Receiving pharmacological treatment for type II diabetes (treatments based on life style interventions are acceptable, as long as they are compatible with the study protocol) Previous gastrointestinal surgery Thyroid disorder History of drug or alcohol abuse Stroke or transient ischemic attack (TIA) within 1 year prior to screening Consumption of drugs aimed at weight management or drugs affecting body weight to a degree that is considered unsuitable for study participation by responsible physician (will be included in the list of allowed/disallowed medications) Pregnant or lactating or wish to become pregnant during the period of the study. Food allergies or intolerances Vegetarian (due to the standardized meals for appetite measurements) Unable to understand written and spoken Swedish Lack of suitability for participation in the trial, for any reason, as judged by the medical doctor or PI.
