Trial | NCT03080818  Report issue

Title

Probiotic on Psychological and Cognitive Effects
Evaluation of a Probiotic on Psychological and Cognitive Effects in Middle and Older Adults

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Indication/Condition

    Aging

  • Study Participants

    200
This study will determine whether supplementation of probiotic Lactobacillus Rhamnosus GG improves psychological status in middle age and older adults through a 12-week, randomized, double-blind, placebo-controlled clinical trial. Secondary analyses will be conducted to examine the possible benefits of probiotic supplementation on cognitive function and markers of physical health.
Study Started
Feb 01
2017
Primary Completion
Jan 01
2019
Study Completion
Jul 01
2019
Last Update
Feb 20
2020

Dietary Supplement Probiotic - Lactobacillus Rhamnosus GG

2 capsules per day for 90 days

Other Placebo

2 placebo capsules per day for 90 days

Probiotic Experimental

Participants in this arm will receive probiotic supplementation for 12 weeks (Lactobacillus Rhamnosus GG)

Control Placebo Comparator

Participants in this arm will receive placebo that look similar to probiotics

Criteria 

Inclusion Criteria:

Age 55-75 years
Able to speak and read English

Exclusion Criteria:

History of neurological, developmental, or severe psychiatric disorder (e.g. dementia, stroke, schizophrenia);
Antibiotic use in the past 30 days;
History of significant stomach or GI surgery (e.g. gastric bypass, cholecystectomy);
History of alcohol or illicit drug dependence;
History of severe heart, kidney, or liver problems (e.g. heart failure, liver failure);
Regular use of an acid-blocking medication in the past 30 days (i.e. proton pump inhibitor, H2 blocker);
Likely immunosuppression (e.g. chemotherapy treatment);
Regular use of other pre- or probiotic supplements in the past 30 days;
Severe gastrointestinal conditions including celiac disease, Crohn's disease, or diverticulitis.
No Results Posted