Trial | NCT03048903  Report issue

Title

The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure
The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    400
Random grouping by computer, divided into two groups, a group of rhubarb treatment group, another group for the placebo group.
Patients were randomly divided into two groups, using rhubarb powder or placebo. Rhubarb is commercially certified rhubarb(Rheum palmatum, Sichuan origin, provided by the pharmacy of my hospital), ground into a powder, over 80 mesh steel mesh, Two days before 6g, three times / day, oral or nasal feeding, two days later reduced to 3g, three times / day, oral or nasal feeding; Another group of patients taking placebo, with the same dose of Rhubarb; The overall course of the two drugs was a week.
Study Started
Feb 29
2016
Primary Completion
Dec 31
2017
Anticipated
Study Completion
Jul 31
2018
Anticipated
Last Update
Feb 09
2017
Estimate

Drug Rheum Palmatum Root

Rhubarb is commercially certified rhubarb(Rheum palmatum , Sichuan origin, provided by the pharmacy of my hospital), ground into a powder, over 80 mesh steel mesh.The dose is 6g in the first 2 days, 3 times / day, oral or nasal feeding,two days later the dose is reduced to 3g, three times / day, oral or nasal feeding.

  • Other names: Chinese Rhubarb Root

Drug Starch Corn

Starch Corn is harmless to people .The use dosage is same as Rheum Palmaturn Root.The dose is 6g in the first 2 days, 3 times / day, oral or nasal feeding,two days later the dose is reduced to 3g, three times / day, oral or nasal feeding.

  • Other names: Medical Starch

Rheum Palmatum Root Experimental

Rheum Palmatum Root is commercially certified rhubarb(Rheum palmatum ,Sichuan origin, provided by the pharmacy of my hospital)

Starch Corn Placebo Comparator

Medical Starch is harmless to people

Criteria 

Inclusion Criteria:

Age:18-65 year old;
Diagnosis: sepsis with gastrointestinal dysfunction (II-III grade AGI); gastrointestinal dysfunction after trauma (II-III AGI);
Complete gastrointestinal tract anatomic structure（including the ileum and colon stoma）

Exclusion Criteria:

Hemodynamic instability;
Underlying diseases: cardiac function III~IV, chronic liver dysfunction Child-Pugh score >9 points;
Less than 5 days after surgery for stomach and small intestine，less than 7 days after Colonic surgery, Postoperative gastrointestinal leakage;
Abdominal Compartment Syndrome;
mechanical ileus
active gastrointestinal hemorrhage
No Results Posted