Title
Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects
Acute Effect of Salbutamol on Heart Rate and Blood Pressure During Exercise in Patients With Moderate or Severe Asthma and Healthy Subjects: Randomized, Double-blind, and Crossover Study
Phase
Phase 4Lead Sponsor
Universidade IbirapueraStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Asthma Heart Rate FastIntervention/Treatment
albuterol ...Study Participants
15Contextualization: Exercise is a common triggers of bronchospasm in patients with asthma and healthy subjects. To prevent these symptoms frequently they have to use Short-Acting Beta2-Agonists. However, the cardiovascular effects of salbutamol during and after exercise remain poorly known.
Objective: To evaluate the effect of salbutamol on heart rate and blood pressure during exercise in patients with moderate or severe asthma and healthy individuals.
Methods: A randomized, double-blind, crossover study will be conducted which 13 individuals with moderate or severe persistent asthma and 13 healthy individuals aged between 20 to 59 years.
Patients will perform a maximal effort test on 2 nonconsecutive days, with either 400mcg Salbutamol or 4 placebo puffs. The order of use of placebo or salbutamol will be drawn. During the protocol, heart rate, blood pressure, perception of exertion and peak expiratory flow will be monitored.
Salbutamol or albuterol is a short-acting β2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and chronic obstructive pulmonary disease.
Neutral preparation for pharmacological effects, given in substitution of a medicine, for the purpose of provoking or controlling reactions, ger. Of a psychological nature, accompanying such a therapeutic procedure.
Salbutamol is a bronchodilator that relaxes the muscles of the airways and increases the flow of air to the lungs. With the aid of a spacer, 400mcg of the drug will be administered once during the protocol.
Inoculant treatment through a substance that does not have an inherent power to produce an effect that is desired or expected. Four placebo puffs will be offered through a device similar to the salbutamol intervention device.
Inclusion Criteria for asthmatics: Have the diagnosis of moderate or severe asthma according to the clinical criteria described in the literature Be between 20 and 59 years of age Being from the Asthma Assistance and Research Center (NAPA) of University of São Paulo Faculty of Medicine Clinics Hospital Have treatment at the outpatient clinic for at least 3 months, Have a stable clinical condition for at least 30 days Make use of the optimized medicine daily Read and signed the TCLE approved by the Ethics and Research Committee of the Ibirapuera University (UNIB) under opinion nº 1,574,833 Exclusion Criteria for asthmatics: Individuals diagnosed with another lung disease, Have psychiatric, musculoskeletal or cardiovascular diseases, Being smokers Being pregnant Practice regular physical activity. Criterion for inclusion of healthy individuals Be between 20 and 59 years of age Healthy individuals Both genders Age between 20 and 59 years Read and signed the TCLE approved by the Ethics and Research Committee of the Ibirapuera University (UNIB) under opinion nº 1,574,833 Criteria for the exclusion of healthy individuals Pregnant women Smokers Psychic diseases Osteomuscular diseases Practitioners of regular exercise Physical Activity Readiness Questionnaire (PAR-Q)
