Trial | NCT03025620  Report issue

Title

Dietary Intake of Alpha-linolenic Acid in Elderly
Investigation of the Relationship Between Alpha-linolenic Acid and Arterial, Biochemical, Biological Parameters in Older Persons With History of Cardiovascular Events and/or Moderate Cognitive Impairment

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    canola oil ...

  • Study Participants

    254
The purpose of this study is to evaluate the antiatherogenic and anti-inflammatory potential of an adequate intake of alpha-linolenic acid in elderly.
There is growing evidence that diets high in long chain n-3 polyunsaturated fatty acids (PUFA) decrease the risk of fatal ischemic heart disease.Both epidemiologic studies and clinical trials demonstrate substantial cardioprotective effects of alpha linolenic acid (ALA) from vegetable oils.However, little is known about the relation of the dietary intake of ALA with ischemic heart disease among older adults.In this study, elderly volunteers will be asked to ingest a supplement of a vegetable oil providing 1g of ALA, or an equivalent amount of linoleic acid as sunflower oil, for a diet period of 6 weeks.Serum samples will be collected before the dietary intervention and 6 weeks later.Plasma biomarkers of inflammatory, lipid cardiovascular risk factors and serum and red cell membrane fatty acid composition will be determined on all samples.
Study Started
Nov 30
2006
Primary Completion
Feb 28
2011
Study Completion
Dec 31
2011
Last Update
Jan 19
2017
Estimate

Dietary Supplement Rapeseed oil

Active comparator arm : Dietary Supplement: rapeseed oil supplementation (10g per day) and margarine with a high level of alpha-linolenic acid (12.5g per day) during 42 days.

  • Other names: Alpha-linolenic acid

Dietary Supplement Sunflower oil

Placebo comparator arm : Dietary Supplement: sunflower oil supplementation (10g per day) and margarine with a high level of inoleic acid (12.5g per day) during 42 days.

  • Other names: Linoleic acid

Sunflower arm Placebo Comparator

Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of sunflower oil (with a high content in linoleic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with sunflower oil (60% fat) that replaced butter on the breakfast toasts.

Rapeseed arm Active Comparator

Participants were supplied with the usual diet of the hospital, daily enriched with 17.5g fat as follows during 42 days: 10 g of rapeseed oil (with a high content in alpha-linolenic acid) were added into the dinner soup and 7.5g delivered through a 12.5g portion of margarine made with rapeseed oil (60% fat) that replaced butter on the breakfast toasts.

Criteria 

Inclusion Criteria:

Elderly patients over 65 years old exhibiting clinical indices of cardiovascular disease
Male or female
Subjects who were hospitalized in the Geriatric Unit of the Emile Roux Hospital (AP-HP)
MMSE (Mini Mental State Examination)score > or = 15
Supervision available for study medication
Able to ingest oral diet

Exclusion Criteria:

Patients unable to understand the objectives of the dietary intervention
Patients in paliative care
Patients receiving supplement diets
No Results Posted