Trial | NCT03017248  Report issue

Title

Low-dose Ketamine for Acute Pain in the Emergency Department
Benefit of the Association of Low Doses of Ketamine With Intravenous Morphine in the Treatment of Acute Severe Pain in Emergency Department

  • Phase

    Phase 1

  • Study Type

    Interventional

  • Status

    Unknown status

  • Indication/Condition

    Pain

  • Study Participants

    125
This study aims to determine the efficacy and safety of low dose ketamine in association with IV morphine in the management of acute moderate to severe pain in emergency department.

The investigators hypothesize that low dose ketamine will result in more effective pain control than morphine alone and will not be associated with an increase in adverse events.
Management of pain in the Emergency Department is challenging. Treatment of pain is most often accomplished by parenteral opioids analgesics. However, the use of opioids alone for pain control is often associated with inadequate analgesia and increased adverse events.

Low-dose ketamine has been shown to improve pain perception and produce an opioid-sparing effect when given perioperatively.

Its use in the ED may probably play a role in maximizing analgesia.
Study Started
Jan 31
2016
Primary Completion
Jun 30
2016
Study Completion
Mar 31
2017
Anticipated
Last Update
Jan 31
2017
Estimate

Drug Ketamine

ketamine

  • Other names: Ketalar, 50 Mg/mL Injectable Solution

Drug Placebos

0.9% normal saline

  • Other names: Normal Saline Flush, 0.9% Injectable Solution

Drug Morphine

Morphine

  • Other names: Morphine Sulfate

Morphine and Placebo Active Comparator

Morphine IV, Dose: 0.1 mg/Kg followed 10 minutes later by an injection of Placebos (0.9% normal saline 0.05ml/kg)

Morphine and Ketamine 0.15 Experimental

Morphine IV, Dose: 0.1 mg/Kg followed 10 minutes later by an IV bolus of Ketamine at the dose of 0.15mg/kg

Morphine and Ketamine 0.3 Experimental

Morphine IV, Dose: 0.1 mg/Kg followed 10 minutes later by an IV bolus of Ketamine at the dose of 0.3mg/kg

Criteria 

Inclusion Criteria:

Able to understand and give informed consent
Comfortable with the experimental protocol as outlined to them by the research team
Severe pain, pain score of at least 50/100 on Visual Analogue Scale (VAS) or 5/10 numerical ratings score
Acute pain, pain duration < 7days
Deemed by treating ED attending physician to require IV opioid analgesia

Exclusion Criteria:

Neurologic, respiratory, or hemodynamic compromise
Pregnancy or breastfeeding
Known or suspected allergy to ketamine or morphine
Known Renal (Cr>2.0) or Liver Failure
Unstable psychiatric disease (as per treating physician)
History of stroke
History of cardiac disease or coronary artery disease
History of chronic respiratory disease
No Results Posted