Title
Molecular Hydrogen for Cognitive Function and Performance in Elderly
Phase
Phase 3Lead Sponsor
University of Novi SadStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Cognitive Impairments AgingIntervention/Treatment
Molecular HydrogenStudy Participants
13A variety of non-pharmacological interventions have been used in the management of Alzheimer's disease (AD) and similar cognitive disorders in elderly, yet no therapeutic modality has demonstrated conclusive positive results in terms of effectiveness. Although it is still unknown what triggers AD, recent studies have shown that AD is associated with brain energy depletion, oxidative stress, and mitochondrial dysfunction. Since supplemental molecular hydrogen (H2) supports cell energy production and acts as a highly bioavailable mitochondria-related antioxidant, it may provide an ideal agent to facilitate treatment and perhaps prevention of AD and similar cognitive disorders in elderly. The overall hypothesis to be evaluated in this project is that administration of H2 will positively affect patient-reported outcomes and clinical biomarkers in men and women suffering from AD.
Molecular hydrogen: 20 min per day of 3% H2 during 4 weeks
Inclusion Criteria: Age over 65 No psychiatric comorbidities Exclusion Criteria: Use of dietary supplements 4 weeks before study commence