Trial | NCT02806128  Report issue

Official Title

The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    100
Evaluate the effectiveness of the of kallikrein in the different drug frequency for acute anterior circulation cerebral infarction.
Study Started
Nov 30
2016
Primary Completion
Dec 31
2018
Anticipated
Last Update
Jan 06
2017
Estimate

Drug Human Urinary Kallidinogenase for Injection

Patients need to complete laboratory tests within a specified time and to complete the experimental requirements of medication time

  • Other names: KLK

Treatment group Experimental

Injection of Human Urinary Kallidinogenase for Injection (KLK) three times a day, 14 days . Patients need to complete laboratory tests within a specified time.

Control group Experimental

Injection of Human Urinary Kallidinogenase for Injection (KLK) Once times a day, 14 days . Patients need to complete laboratory tests within a specified time.

Criteria 

Inclusion Criteria:

Age 18 to 80 years old;
First time diagnosed or have history of acute anterior circulation cerebral infarction without serious sequelae (mRS = 0-2);
Acute anterior circulation cerebral infarction with large artery atherosclerotic etiology;
Ability to randomize within 48 h of time last known free of new ischemic symptoms.
National Institute of Health stroke scale(NIHSS) ranges from 7 to 22;
signed written informed consent.

Exclusion Criteria:

Cerebral CT shows cerebral hemorrhage disease: cerebral hemorrhage, subarachnoid hemorrhage, etc.;
Transient ischemic attack;
Serious disturbance of consciousness: Glasgow Coma ScaleGCS（GCS）≤8;
Combined angiotensin-converting enzyme inhibitor(ACEI) less than 5 half-time (according to its instruction), or need to be treated with ACEI;
Past or present suffering from hemorrhagic tendency of the disease;
The investigator in consideration of the other condition that the patients doesn't fit to participate in this clinical study.
No Results Posted