Trial | NCT02782429  Report issue

Official Title

The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    50
The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on morbidity / mortality in this population.
Study Started
Apr 30
2016
Primary Completion
May 31
2017
Anticipated
Last Update
May 25
2016
Estimate

Drug Ketamine

Other Saline

Ketamine Experimental

This group received ketamine in a dose 0.5 mg / in anesthesia, in addition to other drugs used for induction, which will be standardized.

Placebo Placebo Comparator

This group received the equivalent volume of saline, in addition to other drugs used for induction, which will be standardized.

Criteria 

Inclusion Criteria:

Patients aged over 50 years.
Be submitted to cardiac surgery by sternotomy and with the use of cardiopulmonary bypass (CPB).
American Society of Anesthesiologists classification 1, 2,3 and 4.

Exclusion Criteria:

Patients undergoing reoperation.
Patients undergoing heart transplantation.
Patients using vasopressor agents and / or ionotropic continuous preoperatively.
Patients with prior endotracheal intubation and consequently Ventilatory Assistance Mechanics.
Patients with documented psychiatric disorders.
Patients with previous cognitive disorders.
Patients with a history of alcohol or drug abuse.
Patients with a history of cerebrovascular accident (CVA) with less than 3 months.
No Results Posted