Trial | NCT02778659  Report issue

Title

Hypnotic Intake and Motor and Cognitive Performances at High Altitude
The Effect of Acute Hypnotic Intake Before a Night at High Altitude on Cognitive and Motor Performances

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    zolpidem ...

  • Study Participants

    22
This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. Healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. Following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of Zolpidem within such conditions.
Study Started
May 31
2016
Primary Completion
Oct 31
2017
Study Completion
Oct 31
2017
Last Update
Jan 05
2018

Drug Zolpidem

The hypnotic will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.

Drug Placebo

The placebo will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.

Zolpidem Normoxia Experimental

Acute zolpidem intake at sea level

Placebo Normoxia Sham Comparator

Acute placebo intake at sea level

Zolpidem Hypoxia Experimental

Acute zolpidem intake at high altitude

Placebo Hypoxia Sham Comparator

Acute placebo intake at high altitude

Criteria 

Inclusion Criteria:

No sojourn above 2500 m during the past 2 months
Coffee intake < 3 cups per day
Non-smoker

Exclusion Criteria:

Respiratory, cardiovascular, metabolic or neuromuscular diseases
Psychiatric disorders
Use of hypnotics within the past year
Dependence syndrome (alcool, drugs, etc)
Severe insomnia or somnolence
No Results Posted