Trial | NCT02732405  Report issue

Title

Study to Investigate Tolerability and Efficacy of MK5172 / MK8742 Without Ribavirin for 12 Weeks in Patients With Chronic HCV G1b Infection With Compensated Cirrhosis
A Multicenter, Open Label, Pilot Study to Investigate Tolerability and Efficacy of MK5172 / MK8742 Without Ribavirin for 12 Weeks in Patients With Chronic HCV G1b Infection With Compensated Cirrhosis (Child-Pugh A5 to A6) and No Response to PR or Prior Failure to First Generation Protease Inhibitors (PIs)

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    120
To assess efficacy (SVR rate) of MK5172 / MK8742 for 12 weeks without RBV in G1b patients with compensated cirrhosis (Child-Pugh A5 to A6) previously failing first gen. PI or non responders to PR.
Study Started
May 31
2016
Primary Completion
Dec 31
2016
Anticipated
Study Completion
Mar 31
2017
Anticipated
Last Update
Apr 08
2016
Estimate

Drug MK5172 /MK8742

tablets of MK-5172 100 mg/MK-8742 50 mg will be administered orally, daily for 12 weeks without ribavirin

MK5172 /MK8742 Experimental

Criteria 

Inclusion Criteria:

Informed consent form signed,
Age > 18 years,
Chronic infection with Hepatitis C virus genotype 1b,
HCV RNA > 100 IU/mL,
HCV patients previously treated by PR with no response or previously treated with first generation PIs (boceprevir, telaprevir, simeprevir) and failing therapy,
Subjects with compensated cirrhosis with Child-Pugh score ranging between A5 to A6. Cirrhosis defined by liver biopsy (METAVIR F4) or non-invasive methods (transient elastography (FibroScan) > 12.5 KPa; or FibroTest or FibroSure > 0.75 with APRI >2),
Hepatic Venous Pressure Gradient (HVPG) > 6 mmHg (only in selected sites),
Albumin level ≥ 3.0 g/dl,
Platelet count ≥ 75 x 103/μL.

Exclusion Criteria:

Child-Pugh score greater than CP-A6,
Patients with HCV genotype 1a, 2, 3, 4, 5, 6,
Have any serious or active medical illness which, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance,
HIV or chronic hepatitis B virus (HBV) infection (HBsAg positive),
Decompensated cirrhosis/previous decompensation,
Pregnancy,
Breast-feeding,
Known hypersensitivity to Grazoprevir, Elbasvir or any of its components,
Albumin level < 3.0 g/dl,
Platelet count < 75 x 103/μl,
Concomitant participation in any clinical trial.
No Results Posted