Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Age 18 years or older
Diagnosis of venous leg ulcer(s), as clinically determined by the investigator by a positive venous reflux test (venous refilling <20 seconds) using Doppler ultrasound for at least 4 weeks prior to screening day, which have not adequately responded to conventional ulcer therapy.

Designated venous leg ulcer meets the following criteria at both the screening and baseline visits. If the patient has multiple ulcers, at least one ulcer must meet the following criteria at both the screening and baseline visits:

Present for at least 4 weeks
CEAP Classification Stage 6
Surface ulcer with an area > 15cm2 post debridement
Viable, granulating wound (investigator discretion)
Ulcers that extend through the epidermis but not through the muscle, tendon, or bone (Stage II or III ulcers as defined by the IAET).
Female patients of childbearing potential must have a negative pregnancy test at screening and must agree to use hormonal contraceptive, intrauterine device, diaphragm with spermicide, condom with spermicide, or abstinence throughout until 2 weeks after the last administration of study drug
Signed informed consent

Exclusion Criteria:

Decrease in size of the designated target ulcer(s) by ≥ 30% during the 7-day screening period
Cannot tolerate or comply with compression therapy.
An ulcer which shows signs of severe clinical infection, defined as pus oozing from the ulcer site
An ulcer positive for β-hemolytic streptococci upon culture
The ulcer has > 50% slough, significant necrotic tissue, bone, tendon, or capsule exposure or avascular ulcer beds
Is highly exuding (i.e. requires daily change of dressing)
Ankle brachial pressure index <0.65
Patients with active systemic infections

Patients with clinically significant medical conditions as determined by the investigator including renal, hepatic, hematologic, neurologic or immune disease. Examples include but are not limited to:

Renal insufficiency as an estimated GFR which is < 30 mL/min/1.7m2
Abnormal blood biochemistry defined as 3 times that of the upper limit of the normal range.
Hepatic insufficiency defined as total bilirubin > 2 mg/dL or serum albumin < 25 g/L
HbA1c > 9%
Hemoglobin < 10 g/dL
Hematocrit < 0.30
Platelet count < 100,000
Presence of an active systemic or local cancer or tumor of any kind (with the exception of non-melanoma skin cancer)
Patients with severe rheumatoid arthritis (with more than 20 persistently inflamed joints, or below lower normal limit blood albumin level, or evidence of bone and cartilage damage on x-ray, or inflammation in tissues other than joints) and other collagen vascular diseases.
Patients with active connective tissue disease
Treatment with systemic corticosteroids (>15 mg/day), or current immunosuppressive agents
Previous or current radiation therapy or likelihood to receive this therapy during study participation
Pregnant or nursing patients
Known prior inability or unavailability to complete required study visits during study participation
Significant peripheral edema as per investigator's discretion
A psychiatric condition (e.g., suicidal ideation) or chronic alcohol or drug abuse problem, determined from the patient's medical history, which, in the opinion of the investigator, may pose a threat to patient compliance
Use of a platelet-derived growth factor within 28 days before screening
Use of any investigational drug or therapy within 28 days before screening
Has any other factor which may, in the opinion of the investigator, compromise participation and/or follow-up in the study