Title
Efficacy Phase IIa Study of CVXL-0107 in Advanced Parkinson's Disease
Double-Blind Randomized Placebo-Controlled Cross-Over Phase IIa Trial to Evaluate Efficacy of CVXL-0107 on Parkinson-Related Symptoms and Levodopa-Induced Dyskinesia in Advanced Parkinson's Disease Patients Using a Levodopa Challenge Test
Phase
Phase 2Lead Sponsor
CleveXel PharmaStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Idiopathic Parkinson DiseaseStudy Participants
21CVXL-0107 a glutamate release inhibitor, has shown evidence of antiparkinsonian and antidyskinetic activity in a macaque model and has shown a significant effect on the UPDRS-III (Movement Disorder Society - Unified Parkinson's Disease Rating Scale) while "ON", as well as an increase of "ON-time" without dyskinesia or without troublesome dyskinesia in a previous phase 2a proof of concept study. This study will confirm the efficacy of CVXL-0107 in combination with optimal dose of levodopa on motor symptoms of Parkinson's disease (PD) .
Phase IIa study, 1:1 randomized, double blind placebo- controlled, with cross-over. Each volunteer patient will be randomly assigned to receive CVXL-0107 or placebo as add-on PD therapy and crossed-over to the other arm in the second sequence of the study. They will be assessed during an acute levodopa challenge test with one intake of the study drug or placebo with a supra-optimal dose of levodopa after 2 weeks of daily treatment with the same study drug or placebo. Patients will be cross-overed to the other treatment and reassessed during a second acute levodopa challenge test after 2 weeks of daily treatment with the study drug or the placebo. The study will evaluate the anti-PD and the anti-dyskinesia efficacy of CVXL-0107 as measured by MDS-UPDRS part III (Movement Disorder Society - Unified Parkinson's Disease Rating Scale) and on levodopa-induced dyskinesia as measured by the AIMS (Abnormal Involuntary Movement Scale).
Study drug (CVXL-0107) 4 times per day for 2 weeks on top of usual treatment for Parkinson disease, followed by one challenge test day: one intake of study drug on top of supraoptimal dose of levodopa. Cross-over to placebo 4 times per day for 2 weeks on top of usual treatment for Parkinson disease, followed by one challenge test day: one intake of placebo on top of supraoptimal dose of levodopa
Placebo 4 times per day for 2 weeks on top of usual treatment for Parkinson disease, followed by one challenge test day: one intake of placebo on top of supraoptimal dose of levodopa. Cross-over to study drug (CVXL-0107) 4 times per day for 2 weeks on top of usual treatment for Parkinson disease, followed by one challenge test day: one intake of study drug on top of supraoptimal dose of levodopa
Inclusion Criteria:
Signed written Informed Consent
Male and female patient aged 40 -75 years
Clinical diagnosis of idiopathic PD according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnosis Criteria
Advanced PD with clear daily motor fluctuations and dyskinesia with optimal levodopa-based therapy
At least 2 hours in "OFF" state per day including morning OFF
Predictable "OFF" in the morning on awakening prior to receiving morning dose of levodopa
During an acute levodopa challenge test : Motor improvement of at least 30% on the MDS-UPDRS part III and AIMS score ≥ 1 at least two time points
Patient with dyskinesia: MDS-UPDRS items 4.1 ("time spent with dyskinesia") and 4.2 ("functional impact of dyskinesia") scores ≥ 1 at Screening
Hoehn and Yahr stages of 2-4 in the "OFF" state at Screening
Stable doses and regimens of antiparkinsonian medications for at least the last month prior to randomization (levodopa, dopamine agonists and selective monoamine oxidase type B inhibitors (selegiline, rasagiline))
Anti-PD therapy intended to remain constant throughout the course of the study
Normal platelets count
Mini-mental state examination (MMSE)≥24 at Screening
PD patient treated by DBS can be included if surgery occurred at least one year before the study
Patient with health insurance
Female of childbearing potential with an effective contraception
Exclusion Criteria:
Any relevant neurologic or psychiatric disease, except idiopathic PD
Any secondary causes for Parkinsonism or other neurodegenerative disorder with Parkinsonism symptoms
Any neurosurgical intervention for PD planned during the study period
Neuroleptics and any D2-receptor antagonists within the last 3 months before Screening
Amantadine, Riluzole, dextromethorphan, apomorphine continuous infusion (pump), morphine, or memantine, during the last month before screening and during the study duration
History of psychosis or treatment with any antipsychotic drugs within the last 2 years
History of seizure or epilepsy, or treatment with anticonvulsant drugs within the last year
Any clinically significant unstable medical illness in the last month before randomization (e.g. unstable angina, unstable vascular disease etc)
Anti-cancer treatment within the 3 months before Screening
Treatment with anticoagulant drugs
Any clinically significant renal (serum creatinine level ≥1.5x ULN or dialysis) or hepatic (liver enzyme values≥2x ULN) disease
Any clinically significant condition that may compromise the safety of patient or the conduct of the study protocol according to Investigators' opinion.
Known genetic disorder of human UDP-glucuronosyltransferase
Participation in another trial with any investigational product within the last month before randomization or intake of any investigational product
Pregnant, breastfeeding or lactating female