Trial | NCT02585908  Report issue

Title

Safety and Efficacy of γδ T Cell Against Gastric Cancer
γδ T Cell Immunotherapy for Treatment of Gastric Cancer

  • Phase

    Phase 1/Phase 2

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    120
In this study, safety and effects of γδT cells on human gastric cancer are going to be investigated.
PBMC of the patient will be separated from peripheral blood. After making them potential cancer killer γδ T Cell and CIK, they will be infused to the patients as immunotherapy.
Study Started
Dec 31
2019
Anticipated
Primary Completion
Dec 31
2021
Anticipated
Study Completion
Dec 31
2022
Anticipated
Last Update
Nov 13
2019

Biological CIK

CIK cells will be used against tumor cells.

Biological γδ T

γδ T cells will be used against tumor cells.

Biological CIK and γδ T

CIK and γδ T cells will be used against tumor cells.

Experimental Group A(control group) No Intervention

regular treatment and follow up

Experimental Group B Experimental

CIK will be used against tumor cells.

  • Biological CIK

Experimental Group C Experimental

γδ T will be used against tumor cells.

Experimental Group D Experimental

CIK and γδ T will be used against tumor cells.

Criteria 

Inclusion Criteria:

Age:30-75
Karnofsky performance status >50
Diagnosis with gastric cancer based on histology or the current accepted radiological measures.
Classification tumor,nodes,metastasis-classification(TNM) stage: Ⅱ,Ⅲ,Ⅳ
Patients who have a life expectancy of at least 12 weeks
Ability to understand the study protocol and a willingness to sign a written informed consent document

Exclusion Criteria:

Any significant medical or psychiatric illness that would prevent the patient from giving informed consent or from following the study procedures.
Known human immunodeficiency virus (HIV) infection.
Active and/or severe infection (e.g. tuberculosis, sepsis and opportunistic infections, active hepatitis B virus (HBV) or active hepatitis C virus (HCV) infection).
Other serious underlying medical conditions, which, in the Investigator's judgment, could impair the ability of the patient.
Pregnancy
No Results Posted