Trial | NCT02570971  Report issue

Title

Mannitol Versus Supportive Care in Ciguatera Fish Poisoning
Mannitol Versus Supportive Care in Ciguatera Fish Poisoning: A Randomized Control Trial

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    mannitol ...

  • Study Participants

    200
Ciguatera poisoning, caused by the ingestion of ciguatoxin-containing fish, is a global public health concern. In the US, the vast majority of ciguatera poisonings occur in Florida, followed by Hawaii and California. Equipoise exists in the medical literature regarding the effectiveness of mannitol therapy in treatment of ciguatera poisoning. While there are many case reports attesting to its utility, the only randomized control trial (RCT) comparing mannitol therapy with supportive care failed to show any significant benefit from mannitol treatment for a variety of clinical outcomes. Investigators therefore propose a second, larger RCT to test this question.
Study Started
Oct 31
2015
Primary Completion
Jun 30
2018
Anticipated
Last Update
Oct 07
2015
Estimate

Drug Mannitol

Control No Intervention

Patients will receive supportive care measures.

Investigational Experimental

Patients will receive 500mL of 20% mannitol

Criteria 

Inclusion Criteria:

History consistent with ciguatera poisoning

Exclusion Criteria:

Minors
pregnant patients
those unable to give consent
severe congestive heart failure or renal failure
No Results Posted