Trial | NCT02569684  Report issue

Official Title

Effects of Prebiotics on GLP-1 in Type 2 Diabetes

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    inulin oligofructose ...

  • Study Participants

    37
The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.
We looked at 6 weeks supplementation with a prebiotic fibre mix of inulin and FOS. Cross over design compared to maltodextrin as placebo. Additional outcome measures: blood glucose, insulin, GLP-2, ghrelin, PYY and leptin after a standardized mixed meal test. Also measured changes in microbiota composition and SCFA in feces before and after intervention/placebo periods, and subjective measures of appetite.
Study Started
Oct 31
2015
Primary Completion
Jan 31
2018
Study Completion
Dec 31
2019
Last Update
Sep 16
2020

Dietary Supplement Prebiotic fibers: oligofructose and inulin

Dietary Supplement Maltodextrin

Arm A Active Comparator

Prebiotic fibers: Oligofructose and inulin

Arm B Placebo Comparator

Maltodextrin

Criteria 

Inclusion Criteria:

diabetes type 2
BMI 18,5 - 40
Not medicated with insulin, GLP-1 analogues or DPP4 inhibitors
Moderate intake of alcohol
Not excessive exercise
Less than 3 kg weight change the last two months
Intake of less than 30 g dietary fiber per day

Exclusion Criteria:

IBD
IBS
Coeliac disease
Have used antibiotics within the last two months
Have used supplements with prebiotics or probiotics the last two months
Pregnancy
No Results Posted