Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Written signed informed consent
Comply with study procedures
Body mass index (BMI) between 18 and 35 kg/m2 inclusive;minimum body weight of 50 kg

Male subjects:

Subjects with female partners of childbearing potential must agree to use a highly effective form of birth control, which entails the use of oral, injected or hormonal methods of contraception or intrauterine device/system by the female partner, in combination with a barrier method (e.g. condom, diaphragm, cervical cap with spermicide) during the study and for 3 months after discontinuation of treatment
Subjects who are sterilised or have a female partner who is sterilised
Subjects with a lifestyle that implies abstinence from sexual activity during the study and for 3 months after discontinuation of treatment

Female subjects:

Confirmed post-menopausal women (no periods for at least one year and follicle stimulating hormone (FSH) levels compliant with post-menopausal status according to reference values)
Subjects agreeing to use highly effective form of birth control, which entails the use of oral, injected or implanted hormonal methods of contraception or intrauterine device/system in combination with a barrier method (e.g. condom, diaphragm, cervical cap with spermicide) during the study and for 3 months after discontinuation of treatment
For females of childbearing potential: females must have a negative urine pregnancy test at screening and admission
Normal physical examination, laboratory values, 12-lead electrocardiogram (ECG) and vital signs
Be current smokers with defined smoking history of ≥10 pack years
Ability to perform reproducible spirometry
Demonstrate an FEV1 ≥80% of their predicted normal
Demonstrate no evidence of airway obstruction
Normal airway responsiveness to inhaled methacholine
Have negative screens for serum hepatitis B surface antigen, Hepatitis C antigen and human immunodeficiency virus (HIV)
Be able to produce a minimum of 0.1g sputum after induction with inhaled hypertonic saline at Visit 0

Exclusion Criteria:

Subjects with an uncontrolled cardiovascular, respiratory, haematologic, immunologic, renal, neurologic, hepatic, endocrine disease, or any condition that might, in the judgment of the Investigator, place the subject at undue risk or potentially compromise the results or interpretation of the study
Any clinically relevant abnormal value or physical finding that may interfere with the interpretation of the study results or constitute a health risk for the subject if he/she takes part in the study
Symptoms, signs or laboratory findings suggestive of an ongoing infective illness at the time of enrolment
A history of respiratory disease including asthma
Donation of more than 1200 mL of blood within 12 months of Visit 0 or, donation of blood in total >500 mL within 3 months prior to Visit 0
Symptoms of any clinically significant illness within 2 weeks pior to Visit 0
A significant history of alcohol abuse or consumption of more than 28 units (male) or 21 units (female) of alcohol per week
A significant history of drug abuse (including benzodiazepines) or positive urine drugs of abuse test