Trial | NCT02481193  Report issue

Official Title

Effects of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    90
The purpose of this study is to investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.
Purpose: To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and postoperative myalgia.

Methods: Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before the induction, at the time of endotracheal intubation, and 5 min after intubation were recorded.
Study Started
Mar 31
2013
Primary Completion
Jan 31
2014
Study Completion
Jan 31
2014
Last Update
Jun 25
2015
Estimate

Drug Cisatracurium

Different doses of cisatracurium pretreatment

  • Other names: Dose

Cisatracurium 0.005 mg/kg Experimental

The group received pretreatment of cisatracurium 0.005 mg/kg.

Cisatracurium 0.01 mg/kg Experimental

The group received pretreatment of cisatracurium 0.01 mg/kg

Cisatracurium 0.02 mg/kg Experimental

The group received pretreatment of cisatracurium 0.02 mg/kg

Criteria 

Inclusion Criteria:

American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia
20 - 65 years old
without acid-base imbalance and electrolyte disturbance
with normal hepatic and renal function

Exclusion Criteria:

Patients with known hyperkalemia
Patients with increased intraocular pressure
Patients with increased intracranial pressure
Patients with symptoms of gastroesophageal reflux
Patients with anticipated airway difficulties
Patients with malignant fever
Patients with neuromuscular disease
Patients with burn or crush injuries
Patients with taking drugs known to alter the action of neuromuscular blockers
Patients with with a body mass index exceeding 30
No Results Posted