Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Male or non-childbearing potential female, which includes post-menopausal female (absence of menses for 12 months prior to drug administration, bilateral oophorectomy or hysterectomy with bilateral oophorectomy at least 6 months prior to drug administration) or surgically sterile female (hysterectomy or tubal ligation at least 6 months prior to drug administration)
Body Mass Index (BMI) greater than or equal to (≥) 27.0 and less than or equal to (≤) 35.0 kilogram per square meter (kg/m2)

Healthy as defined by:

absence of clinically significant illness and surgery within last 4 weeks. Participants vomiting within 24 hours pre-dose will be evaluated for upcoming illness/disease
the absence of clinically significant history of neurological, endocrine, cardiovascular, pulmonary, hematological, immunologic, psychiatric, gastrointestinal, renal, hepatic, or metabolic disease

Male participants who are not vasectomized for at least 6 months, and who are sexually active with non-sterile female partner (sterile female partners include post-menopausal females and surgically sterile females) must be willing to use one of the following acceptable contraceptive methods throughout the study and for 90 days after the last study drug administration:

simultaneous use of a condom, and for the female partner hormonal contraceptives (used since at least 4 weeks) or intra-uterine contraceptive device (placed since at least 4 weeks)
simultaneous use of a male condom, and for his female partner, a diaphragm with intravaginally applied spermicide

Some degree of insulin resistance, as shown by:

fasting blood glucose ≥95.4 and ≤126 milligrams per deciliter (mg/dL) (equivalent to 5.3 to 7.0 millimoles per liter (mmol/L), respectively) and
fasting triglycerides ≤ 4.0 mmol/L, and/or
Low-Density Lipoprotein Cholesterol (LDL-C) ≤ 6.0 mmol/L
Capable of consent
Non-smoker (no use of tobacco products within the last 3 months)

Exclusion Criteria:

Any clinically significant abnormality or abnormal laboratory test results (other than glucose,triglycerides and LDL-C levels described in inclusion criterion)
Positive test for hepatitis B, hepatitis C, or Human Immunodeficiency Virus (HIV)
Evidence of clinically significant hepatic or renal impairment, including Alanine Aminotransferase (ALT) above 1.5x Upper Limit of Normal (ULN), Aspartate Aminotransferase (AST) above 2x ULN, total bilirubin above 2x ULN (total bilirubin accepted up to 2x ULN if direct bilirubin is within normal limits), or Estimated Glomerular Filtration Rate (eGFR) less than (<) 90 milliliters per minute (mL/minute)
Positive urine drug screen
History of significant allergic reactions (e.g. angioedema) to any drug.
Use of any drugs known to induce or inhibit hepatic drug metabolism within the last 30 days
Positive pregnancy test
Any reason which, in the opinion of the qualified investigator (QI) would prevent the subject from participating in the study

Clinically significant electrocardiogram (ECG) abnormalities at screening, or clinically significant personal or family history (in a first-degree relative) of heart diseases, including:

Confirmed corrected QT (QTcF) interval greater than (>) 450 milliseconds (msec) for men and women
Bundle branch blocks and other conduction abnormalities other than mild first degree atrio-ventricular block
Irregular rhythms other than sinus arrhythmia or occasional, rare supraventricular ectopic beats
History of unexplained syncope
Family history of unexplained sudden death or sudden death due to long QT syndrome
T-wave configurations are not of sufficient quality for assessing QT interval
Clinically significant vital sign abnormalities (systolic blood pressure lower than 90 or over 150 mmHg, diastolic blood pressure lower than 50 or over 95 mmHg, or heart rate less than 50 or over 100 beats per minute (bpm))
History of significant alcohol abuse within one year prior to screening or regular use of alcohol within six months prior to the screening (regular use of more than three units of alcohol per day for males and more than two units of alcohol per day for females [1 unit = 150 (milliliter) mL of wine, 360 mL of beer, or 45 mL of 40% alcohol]) or positive alcohol breath test
History of significant drug abuse within the last year or use of soft drugs (such as marijuana) within 3 months prior, or hard drugs (such as cocaine, phencyclidine (PCP) and crack) within the last year
Participation in a clinical trial involving the administration of an investigational or marketed drug within the last 30 days (90 days for biologics) or concomitant participation in an investigational study

Use of medication other than topical products without significant systemic absorption:

prescription medication within last 14 days
over-the-counter products within the last 7 days, with the exception of the occasional use of acetaminophen (up to 2 grams (g) daily)
natural health products (e.g. food supplements or herbal supplements) within last 14 days
a depot injection or an implant of any drug within last 3 months
Donation of plasma within the last 7 days. Donation or loss of blood of 50 mL to 499 mL of blood within 30 days, or more than 499 mL within 56 days
Hemoglobin <128 grams per liter (g/L) (males) and <115 g/L (females) and hematocrit <0.37 L/L (males) and <0.32 L/L (females)
Breast-feeding participant