Trial | NCT02366585  Report issue

Official Title

The Effect of Locally Delivered Ciclosporin as an Adjunct to Healing After Treatment of Periodontal Pockets

  • Phase

    Phase 2

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    23
The main purpose of the trial is to investigate the effect of locally delivered ciclosporin as an adjunct to non-surgical mechanical debridement in the treatment of chronic periodontitis and to compare it to mechanical debridement alone.
Study Started
Mar 31
2015
Primary Completion
Sep 30
2016
Study Completion
Oct 31
2016
Last Update
Apr 07
2017

Drug Ciclosporin

Ciclosporin gel applied to two periodontal pockets

Treatment with Ciclosporin Experimental

Treatment of two periodontal pockets with ciclosporin gel Non-treatment of two periodontal pockets in same patient as comparator

Criteria 

Inclusion Criteria:

Patients in good general health
2 pairs of contralateral interproximal periodontal sites with probing depths of ≥7mm in single-rooted teeth not associated with furcations or root furrows.The test sites should have a distance of at least two teeth to the control sites.
Teeth selected should have a vital pulp as determined by thermal or electric stimulation

Exclusion Criteria:

Patients already included in other clinical trials involving therapeutic intervention (either medical or dental)
Periodontal treatment during the last 6 months
Antibiotic treatment 6 months prior to the start of the trial
Antibiotic prophylaxis required for dental treatment
Patients with acute infectious lesions in the areas of intended treatment
Regular anti-inflammatory medication
Known history of ciclosporin allergy
Ongoing medication that may affect the clinical features of periodontitis
Patients who are smokers
Patients that are immuno-compromized or on immunosuppressive medication
Patients who are pregnant or lactating
No Results Posted