Trial | NCT02329353  Report issue

Title

Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
Clinical And Microbiological Analysis Of Orally Administered Lactobacillus Probiotic Lozenges In Chronic Periodontitis Patients Among Smokers And Non-smokers And Its Correlation With Clinical Parameters - A Clinico-Microbiological Study

  • Phase

    Phase 3

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    60
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species. The periodontal destruction is substantially mediated by the host, driven by the bacterial challenge. The presence of pathogenic bacteria with the absence of so-called "beneficial bacteria" and the susceptibility of the host are the main aetiological factors of periodontal diseases.
Study Started
Feb 28
2015
Primary Completion
Nov 30
2016
Study Completion
Dec 31
2016
Last Update
Jan 10
2017
Estimate

Drug Lactobacillus brevis CD2 Lozenges

Each lozenge contains not less than 1 billion Colony forming unit of Lactobacillus brevis CD2

  • Other names: Probiotics

Smoker group Experimental

30 chronic periodontitis patients, having habit of smoking, with probing pocket depth of equal or greater than 5 mm with bleeding on probing and radio-graphic evidence of bone loss in at at least 2 sites at each quadrant will be given three probiotic lozenge per day for 8 weeks

Non-smoker Experimental

30 chronic periodontitis patients, not having habit of smoking, with probing pocket depth of equal or greater than 5 mm with bleeding on probing and radio-graphic evidence of bone loss in at at least 2 sites at each quadrant will be given three probiotic lozenge per day for 8 weeks

Criteria 

Inclusion Criteria:

Patients free from any systemic illness
Previously untreated moderate to severe generalised chronic periodontitis.
Patients free from adverse reactions to lactose or fermented milk products
Patient unwilling to quit smoking and smokers over the past one year ( Smoker arm).

Exclusion Criteria:

Previous history of antibiotic usage over past 6 months
Patients who are eligible for antibiotic usage during the treatment course
Patients who are pregnant, lactating, alcoholic or who had undergone any surgical or nonsurgical therapy within 6 months.
Acute oral lesions or necrotising ulcerative periodontitis
No Results Posted