Trial | NCT02159170  Report issue

Title

Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor
Cortical Representation of NGF-induced Hyperalgesia

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    20
Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.
Study Started
Mar 31
2014
Primary Completion
Dec 31
2014
Study Completion
Dec 31
2014
Last Update
Jan 16
2015
Estimate

Biological NGF injection

single injection of NGF into the volar forearm / single injection of NaCl into the volar forearm

NGF Experimental

injection of 50 µl NGF, once into the left volar forearm and injection of 50 µl NaCl (sodium chloride) once into the right volar forearm

Criteria 

Inclusion Criteria:

no acute or chronic disease
no acute or chronic pain
age: 18-60 years
male
no medication use

Exclusion Criteria:

metallic parts in the body
claustrophobia
drug or substance abuse
No Results Posted