Trial | NCT02090842  Report issue

Title

Milk Proteins, Ambulatory Blood Pressure and Vascular Function
Investigating the Acute and Chronic Effects of Dietary Proteins on Markers of Vascular Function, Ambulatory Blood Pressure, Insulin Resistance and Lipid Metabolism.

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    38
Epidemiological studies demonstrated an inverse associations between cardiovascular events and milk and dairy product consumption. Evidence from human intervention studies suggests that both whey and casein may be effective in blood pressure-lowering, however there is limited data on the impact of milk proteins on vascular function. This research aims to compare the potential acute and chronic impacts of the two main milk proteins (whey and casein) with maltodextrin on blood pressure and vascular function. Furthermore, the effects of these proteins on the markers of insulin resistance, lipid metabolism and inflammatory status will also be investigated in 'at-risk' individuals.

This research includes both an acute and chronic intervention study which have been independently powered on the appropriate outcome measures. This has generated different sample size requirements for the two studies (Actual participants on the acute study: n=27, and on the chronic study: n=38).
Study Started
Feb 28
2014
Primary Completion
Feb 28
2015
Study Completion
Feb 28
2015
Last Update
Jan 11
2016
Estimate

Dietary Supplement Ca-caseinate

Dietary Supplement Maltodextrin

Dietary Supplement Whey protein isolate

Whey protein isolate Experimental

Subjects are asked to supplement their habitual diet with 56 g of whey protein isolate a day for 8 weeks.

Ca-caseinate Experimental

Subjects are asked to supplement their habitual diet with 56 g of Ca-caseinate a day for 8 weeks.

Maltodextrin Other

Subjects are asked to supplement their habitual diet with 54 g of maltodextrin a day for 8 weeks.

Criteria 

Inclusion Criteria:

A signed consent form
Blood pressure: 120/80-159/99
Age: 30-77 years
BMI 20-40 kg/m2
Glucose <7 mmol/l (Not diagnosed with diabetes)
Chol <8 mmol/l
TAG <4 mmol/l
Normal liver and kidney function
Haemoglobin (>110 g/dl women; 140g/dl men)

Exclusion Criteria:

Milk allergy, lactose allergy
Coeliac disease
Renal, gastrointestinal, respiratory, endocrine, liver disease or cancer
Surgery in the previous 6 months
Secondary hypertension
Excess alcohol consumption (drinking >28 unit/wk man; >21 unit/wk women)
Smoker
Vegan
Taking nutritional supplementation (e.g. fish oil, proteins)
Anaemia
No Results Posted