Trial | NCT01955759  Report issue

Title

Atrial Fibrillation and By-pass Surgery
Pharmacologic Prophylaxis for Atrial Fibrillation Following Coronary By-Pass Surgery

  • Phase

    Early Phase 1

  • Study Type

    Interventional

  • Status

    Unknown status

  • Study Participants

    260
The aim of the study is to evaluate whether combined therapy with beta-blocker, amiodarone and statine is better than beta-blocker alone for the prevention of atrial fibrillation after coronary by-pass surgery.
Study Started
Dec 31
2013
Primary Completion
Dec 31
2014
Anticipated
Study Completion
Feb 28
2015
Anticipated
Last Update
Dec 17
2013
Estimate

Drug Amiodarone tab 200 mg x 3

starting 7 days before coronary by-pass surgery per os 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge

  • Other names: cordarone

Drug rosuvastatin 20 mg tab x1

starting 7 days before coronary by-pass surgery

  • Other names: crestor

Drug beta blockers Bisoprolol in adjusted dose

starting 7 days befoe coronary by-pass surgery

  • Other names: zebeta

beta blocker and amiodarone Experimental

The inteventin will be that patients will receive beta blocker Bisoprolol in adjusted dose + Amiodarone per os starting 7 days before coronary by-pass surgery, 200 mg. x 3 tab, followed by 200 mg x 2 tab per os starting on the second postoperative day untill discharge

beta blocker and statin Experimental

The intervention will be that patients will receive beta blocker (Bisoprolol tab in adjusted dose)+ Rosuvastatin 20 mg. x 1 starting 7 days before coronary by-pass surgry untill discharge.

beta blocker Placebo Comparator

Patients will receive beta blocker (Bisoprolol tab in adjusted dose).

Criteria 

Inclusion Criteria:

significant coronary disease, sinus rhythm

Exclusion Criteria:

valvular disease, former by-pass surgery
No Results Posted