Trial | NCT01939093  Report issue

Title

Therapeutic Effect of Quetiapine on Methamphetamine-Induced Psychosis
Therapeutic Effect Between Quetiapine and Haloperidol on the Treatment of Methamphetamine - Induced Psychosis

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    80
The aims of this study are to compare the antipsychotic and adverse events of quetiapine, an atypical antipsychotic drug, to haloperidol, a standard treatment for primary psychotic disorder, in individuals with MAP.
Eighty individuals with MAP will be randomly assigned into two treatment groups, i.e. treatment with quetiapine and haloperidol. The quetiapine group will receive quetiapine at least 100 mg per day and the haloperidol group will receive haloperidol at least 2 mg per day orally once a day for four weeks. The doses will be increased every 5 days until no psychotic symptom is observed from the Positive and Negative Syndrome Scale. Common antipsychotic adverse events will be checked and documented daily.
Study Started
Mar 31
2010
Primary Completion
Sep 30
2011
Study Completion
Sep 30
2011
Last Update
Sep 11
2013
Estimate

Drug Diazepam

If subjects had aggressive or violent symptoms and immediate symptom control was needed, 10 mg of diazepam (intravenous injection) every 4 hours is allowed for symptom control.

Dietary Supplement Vitamin B1-6-12

All subjects will be given the Institute's medication regimen, including vitamin B1-6-12 1 tablet three times a day after meals during the whole study period.

Drug Stugeron

All subjects will be given the Institute's medication regimen, including stugeron 1 tablet three times a day after meals during the whole study period.

Quetiapine Experimental

Quetiapine 100 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.

Haloperidol Active Comparator

Haloperidol 2 mg per day is taken orally once a day for four weeks. The dose is increased every 5 days until no psychotic symptom is observed.

Criteria 

Inclusion Criteria:

Having a psychotic episode with current use of methamphetamine
Positive urine toxicology test for methamphetamine on the first day of hospitalization

Exclusion Criteria:

Using other illegal substances
Having a history of primary psychotic disorders or using antipsychotic agents
Having a chronic medical disease, e.g. essential hypertension, diabetes, epilepsy, stroke
No Results Posted