Title
Efficacy Study of Vx001 Vaccine in NSCLC Patients
Phase II Study of Vx001 Vaccine in HLA-A*0201 Positive Patients With TERT Positive Stage IV or Recurrent Stage I-III NSCLC
Phase
Phase 2Lead Sponsor
Vaxon BiotechStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Non-small Cell Lung Cancer MetastaticIntervention/Treatment
vx-001 ...Study Participants
221Patients with stage IV or recurrent stage I-III NSCLC with documented disease control (objective response or stable disease) within 3 weeks after platinum based 1st line chemotherapy; only HLA-A*0201 positive patients with TERT expressing tumors will be included.
The objective of the trial is survival rate at 12 months.
Main Inclusion Criteria: Male or female ≥18 years of age; Documented stage IV NSCLC as defined by IASLC Lung Cancer Staging Project (7th edition) or recurrent stage I-III disease at least 6 months after resection or after the end of adjuvant chemotherapy or after standard locoregional treatment as defined by the American College of Chest Physicians; Patients treated with 4 cycles platinum based 1st line chemotherapy as defined by the American College of Chest Physicians (i.e. radiotherapy are not allowed except palliative radiotherapy of bone metastasis); Documented HLA-A*0201 positivity, as determined by a local laboratory; TERT-positive NSCLC, as assessed by a central laboratory; for this, availability of adequate tissue biopsy from the primary tumor, lymph nodes or distant metastases is a prerequisite; CR, PR, or SD according to RECIST 1.1 criteria after the completion of platinum-based first-line chemotherapy; ECOG performance status 0, 1; Main Exclusion Criteria: Mixed small cell and NSCLC histologies; Patients with stage IV or recurrent NSCLC who have been previously treated with therapy other than platinum-based first-line chemotherapy; Prior treatment with cancer vaccines; Prior treatment with immunotherapy (e.g., interferons, interleukins, TNF, or biological response modifiers, such as GM-CSF etc) within four weeks prior to randomization; Prior treatment with hormone (including corticosteroids) within 2 weeks prior to randomization; Prior treatment with any investigational drugs, within 4 weeks prior to randomization; Patients with brain metastases;