Trial | NCT01903785  Report issue

Title

Salbutamol, Pharmacogenetics and Breathing Mechanics
The Pharmacogenetic Effects of Inhaled Salbutamol on Breathing Mechanics and Cycling Performance

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Intervention/Treatment

    albuterol ...

  • Study Participants

    94
Athletes using asthma medications called β2-agonists win a disproportionately high number of medals at Olympic Games. Due to a large variety in the genes that affect how individuals respond to β2-agonists, the investigators will look at variations in the genetic response to these medications by dividing athletes into high-responders and low-responders. The investigators will then compare athletic performance after the inhalation of β2-agonists to placebo. Furthermore, the investigators will analyze the effect of β2-agonists on breathing mechanics. Due to differences in their anatomy females may decrease the energy needed for breathing during high-intensity exercise to a greater extent compared to male athletes after the inhalation of β2-agonists.
Study Started
May 31
2013
Primary Completion
Dec 31
2014
Study Completion
Aug 31
2016
Last Update
Nov 02
2016
Estimate

Drug Salbutamol

60 minutes prior to the start of a 10km cycling time trial on a bike ergometer, subjects will inhale either 400ug of salbutamol 1600ug of salbutamol or 400ug of placebo in a randomly assigned manner in a single dose.

  • Other names: ventolin

Drug Placebo

Salbutamol Experimental

400ug of salbutamol (one single inhalation) will be inhaled 60min prior to the begin of a time trial. Mean power output during the following 10km time trial will be described to 1600ug salbutamol and placebo.

Placebo Placebo Comparator

400ug of placebo (one single inhalation) will be inhaled 60min prior to the begin of a time trial. Mean power output during the following 10km time trial will be described to 400ug and 1600ug salbutamol.

Criteria 

Inclusion Criteria:

trained, experienced cyclists
maximal oxygen consumption of at least 50ml/kg/min or 4l/min for women; and 60ml/kg/min or 5l/min for men
athletes with and without exercise-induced bronchoconstriction

Exclusion Criteria:

any uncontrolled heart or lung condition
maximal oxygen consumption of less than 50ml/kg/min or 4L/min for women; and less than 60ml/kg/min or 5L/min for men
pregnancy
smoking
No Results Posted