Title
Drug Combination on Exercise Performance at High Altitude
Enhancing Physical Performance and Mitigating Acute Mountain Sickness Via Pharmaceutical Intervention While at Altitude
Phase
Phase 2/Phase 3Lead Sponsor
University of MontanaStudy Type
InterventionalStatus
Completed Results PostedIndication/Condition
Acute Mountain SicknessIntervention/Treatment
theophylline ambrisentan ...Study Participants
28This study is being conducted to determine the effectiveness of using two FDA approved medications in concert to reduce the likelihood of sickness due to low oxygen levels and to reduce the decrement in physical performance at higher elevations. The investigators hypothesize that this drug combination will reduce the symptoms of acute mountain sickness and improve exercise performance at high altitude compared to placebo.
placebo for comparison group
ambrisentan (5mg) once daily for 2 consecutive days theophylline (400mg) once daily for 2 consecutive days
matched placebo tablets wil be given at the same time to the comparison group as the medications to the experimental group
Inclusion Criteria: healthy males Exclusion Criteria: VO2max below 45ml/kg/min currently taking any medication
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