Trial | NCT01895530  Report issue

Title

Impact of Probiotics in Modulation of Intestinal Microbiota
Impact of Probiotics in Modulation of Intestinal Microbiota of Patients Undergoing a Resection Colonic

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    33
The investigators would study about impact of the administration of probiotics in the intestinal mucosa of patients undergoing resection colic, by evaluating cytokine profile by quantitative real time PCR. The investigators believe that patients who use probiotic preoperative would provide cytokine profile less inflammatory than those of the control group.
Samples of colorectal cancer-free mucosa derived from patients who underwent surgical resection were investigated. Quantitative real-time polymerase chain reaction (RT-qPCR) was used to determine expression levels of the following genes: IL10, IL1B, IL23A, TNF, IL12B, INFG, IL17A.
Study Started
Jul 31
2010
Primary Completion
Aug 31
2011
Study Completion
May 31
2012
Last Update
Jul 10
2013
Estimate

Dietary Supplement Saccharomyces boulardii

The patients received one oral lyophilized yeast capsule, each of which contains 100 mg (0,5 x 109 cfu/g) of Saccharomyces boulardii (Merck S.A., Biocodex, Beauvais, French), once a day. The treatment started at least seven days before surgery and stopped on the operation day.

Control group No Intervention

Conventional treatment with no probiotic supplementation

Probiotic group Experimental

The patients received one oral lyophilized yeast capsule, each of which contains 100 mg (0,5 x 109 cfu/g) of Saccharomyces boulardii (Merck S.A., Biocodex, Beauvais, French), once a day. The treatment started at least seven days before surgery and stopped on the operation day.

Criteria 

Inclusion Criteria:

if he or she were older than 18 years
intended to undergo elective CRC resection at UFMG Hospital

Exclusion Criteria:

Patients were excluded if they were not able to receive the probiotics seven days before the operation
if colon resection was not performed due to changes in operation strategy, or if they discontinued probiotic use on their own or
if they removed their consent.
No Results Posted