Trial | NCT01875952  Report issue

Title

Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL)
Integral Research of the Managing and Treatment of the Infection With Human Immunodeficiency (VIH) /Human Immunodeficiency Syndrome(SIDA) Co-infection With Latent Tuberculosis Infection. A Multidisciplinary and Interinstitucional Approach

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Unknown status

  • Intervention/Treatment

    isoniazid ...

  • Study Participants

    100
The purpose of this study is to determine of once identified to the subjects infected with human immunodeficiency virus (positive VIH), to diagnose latent Tuberculosis, and to treat her with isoniazid for six months, measuring the production of Interferon range pre and posttreatment, to evaluate this way the result of the treatment on the immune response
A descriptive analysis of the data will be made. Means and standard deviations for continuous data frequencies for categorical data will be performed. Wilcoxon test Mann-Whitney U test Chi square will be used for frequency analysis of responders Data Analysis and Statistical Software(STATA).
Study Started
May 31
2010
Primary Completion
Jun 30
2012
Study Completion
Jun 30
2013
Anticipated
Last Update
Jun 12
2013
Estimate

Drug Isoniazid

Isoniazid, 10 mg/Kg/day, no more than 300 mg/day, for six months

one arm Other

All patients with response to positive purified protein derivative (PPD) test are treated

Criteria 

Inclusion Criteria:

Accept to participate. Informed consent.
Human Immunodeficiency Virus positive test, documented by Western Blot
Have not received treatment for latent tuberculosis
Have not been diagnosed pulmonary tuberculosis (Tbp)
Normal two chest X-rays, Postern-anterior and left lateral.

Exclusion Criteria:

Active tuberculosis
Previous diagnosis of tuberculosis
Antecedent of treatment for active o latent tuberculosis
Contact with TB patient harboring Multidrug resistance or isoniazid resistant isolates of Mycobacterium tuberculosis.
Abnormal liver enzyme levels
Hemoglobin below 8 gr/dl
Allergy or intolerance to isoniazid
Peripheral neuropathy
Ingestion of drugs interacting with isoniazid
No Results Posted