Trial | NCT01827020  Report issue

Title

Effect of Ketamine Addition to Lidocaine in Rhinoplasty
Effect of Ketamine Addition to Lidocaine for Postoperative Pain Management in Rhinoplasty

  • Phase

    Phase 4

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    90
The purpose of this study is to determine whether subanesthetic ketamine addition to lidocaine decreases postoperative pain scores in infiltration anesthesia during rhinoplasty.
In rhinoplasty operations local infiltration anesthesia uses for surgery insight and patient comfort. The investigators designed this study to prolonged the time of infiltration block and preventive analgesia. So, before operation, study drugs will infiltrate to the submucosa of intranasal cavity. Then, surgeon and patient satisfaction, postoperative analgesic demand, postoperative pain scores and side effects will determine.
Study Started
Jan 31
2013
Primary Completion
Feb 28
2013
Study Completion
Mar 31
2013
Last Update
Apr 09
2013
Estimate

Drug Lidocaine 2 %

12 mL lidocaine 2% 1mg/kg

  • Other names: preincisional infiltration of lidocaine

Drug Ketamine plus Lidocaine

ketamine 0.5 mg/kg + Lidocaine 2% 1 mg/kg in total volume of 12 mL

  • Other names: preincisional infiltration of ketamine plus lidocaine

Drug Saline

12 mL saline (0.9% isotonic solution)

  • Other names: preincisional infiltration of saline

Group L (number of participants=30) Active Comparator

After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of 12 mL lidocaine 2%, 1mg/kg into nasal cavity.

Group K (number of participants=30) Active Comparator

After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of 12 mL ketamine 0.5 mg/kg plus lidocaine 2% 1 mg/kg of the intranasal cavity.

Group S (number of participants=30) Placebo Comparator

After standard anesthesia induction and before surgery, patients will receive submucosal infiltration of saline 12 mL into intranasal cavity.

Criteria 

Inclusion Criteria:

Patients scheduled for elective rhinoplasty operation under general anesthesia
Patients with ASA (American Society of Anesthesiology) class I
Patients between 18-50 years old

Exclusion Criteria:

Age <18 and >50
ASA > II
Preexisting neurological or psychiatric illness
Systemic diseases (diabetes mellitus, hypertension, coronary heart disease...)
Having a history of chronic pain and receiving chronic analgesia therapy
Having a history of drug abuse
No Results Posted