Clinical Drug Experience Knowledgebase

Criteria

Inclusion Criteria:

Age: ≥ 18 and ≤ 75 years, both male and female;
Radical hepatectomy has been performed for hepatocellular carcinoma;
The hepatocellular carcinoma has been confirmed by pathological examination;
Barcelona clinic liver cancer(BCLC) stage A or B;
Not receiving any preoperative anticancer drug;
The liver and kidney function satisfies the following conditions within 15 days after surgery (excluding day 15): aspartate aminotransferase(AST), glutamic-oxalacetic transaminase(ALT)<3 upper limit of normal(ULN), total bilirubin≤2ULN, serum creatinine <1.5 ULN;
Other laboratory tests meet the following requirements within 15 days after surgery (excluding day 15): Hb≥9g/dl, platelet count≥60×109/L, absolute neutrophil count>1.0×109/L;
The expected survival time ≥ 12 weeks;
The subjects volunteer to sign the informed consent.

Exclusion Criteria:

Hepatocellular carcinoma patients who received non-radical hepatectomy;
Non-hepatocellular carcinoma patients;
Those with Child-Pugh C;
Pregnant or lactating women;
Those with active bleeding due to various reasons;
Those with HIV infection or AIDS-associated diseases;
Those with severe acute and chronic diseases;
Those with severe diabetes;
Those with serious infectious diseases;
Those who can not take drugs by oral route;
Drug abusers or those with psychological or mental diseases that may interfere with study compliance;
Conditions that are considered not suitable for this study investigators