Title
Study of Zonisamide in Early Parkinson Disease
Randomized Double Blind Placebo-controlled Study of Zonisamide Effectiveness in Early Parkinson Disease
Phase
Phase 2/Phase 3Lead Sponsor
Mazandaran University of Medical SciencesStudy Type
InterventionalStatus
WithdrawnIndication/Condition
Parkinson DiseaseIntervention/Treatment
zonisamide ...Study Participants
0The aim of this study is investigation of neuroprotective effect of zonisamide in early Parkinson disease. A total of 60 patients with early Parkinson disease who meet the study criteria will be enrolled and randomized into two groups alternately based on their visit date. Demographic data, Unified Parkinson's Disease Rating Scale (UPDRS), modified Hoehn&Yahr and modified Schwab&England activities of daily living scale will be determined and registered for each patient. Patients of group A will be treated by zonisamide 50mg/d for 12 months and the other group will be treated by placebo for the same time. Primary endpoint is occurrence of parkinsonian symptoms which interfere with patients' daily activity or cause psychosocial embarrassment. The mentioned scores will be registered every 2 months for both groups by blinded neurologist and also regular blood test will be performed to prevent drug adverse events.
The first arm will be treated by zonisamide
The second arm will receive placebo
The patients in this arm are treated with zonisamide 50mg/d
Inclusion Criteria: Age 45-85 years Symptoms and signs of idiopathic Parkinson disease for less than a month that do not lead to physical or psychosocial disability. Exclusion Criteria: Past history of treatment with antiparkinson drugs. Past history of treatment with zonisamide Hepatic insufficiency (ALT>2ULN) Renal insufficiency (Cr>2mg/dl) Self or family history of nephrolithiasis Active psychosis Epilepsy Suicidal attempt in last 3 years Hypersensitivity to sulfonamides Pregnancy and breastfeeding
