Trial | NCT01761045  Report issue

Title

Effect of Monosodium L-Glutamate (MSG) and Nucleic Acid (IMP) on Satiety and Food Intake
A Randomized, Double-Blind, Placebo-Controlled, Crossover Clinical Study of Monosodium L-Glutamate (MSG) and Nucleic Acid (IMP) to Evaluate the Effects on Satiety and Food Intakes at the Next Meal in Healthy Adults

  • Phase

    N/A

  • Study Type

    Interventional

  • Status

    Completed No Results Posted

  • Study Participants

    80
The objective of this study is to confirm that Monosodium L-Glutamate (MSG) supplementation, both alone or in combination with Nucleic Acid (IMP), enhances satiety and decreases food intakes at the next meal in healthy female adults.
The study is a randomized, double-blind, placebo-controlled, cross-over clinical trial. A total of 80 women aged 30 to 45 y will be randomized to a sequence of test product administration.

Subjects will be required to meet several inclusion and exclusion criteria, which will be assessed at the screening visit, including a general screening questionnaire, medical/medication history, eating disorder questionnaire, eating inventory questionnaire, dietary inventory questionnaire, and anthropometric and vital sign measurements. At the screening visit, a urine sample will be collected for drug and alcohol screening, cotinine level, and pregnancy. Alcohol breath test will be performed as well.

After assessment of the eligibility criteria, qualified subjects will be invited to participate in the study. This study will take approximately 3 weeks to complete.

Subjects will return to the study site within 28 days after the screening visit for testing period 1, followed by 2 additional visits (testing period 2 and 3).

Subjects will consume 1 of 3 treatments, based on randomization sequence at each test period visit: Consommé soup with Monosodium L-Glutamate (MSG), Consommé soup with MSG and Nucleic Acid (IMP), and Placebo soup with no MSG or IMP.

When subjects arrive at the research center at approximately 11:30am, admission procedures will be conducted: an alcohol breath test, food and activity diary review, and vital signs and weight will be measured. If vital sign measurements are elevated, subjects will be rescheduled within 2-3 days. Right before serving the standard lunch meal, subjects will be asked to complete a satiety motivational questionnaire. Subjects will consume the entire standard lunch meal and water within 30 min. Immediately after eating the standard lunch meal, subjects will complete the satiety motivational questionnaire.

Two hours after the standard lunch meal, subjects will be given one of the test soups (based on their randomization) to consume in its entirety, followed by completion of the satiety motivational questionnaire and the soup rating questionnaire. Fifteen minutes from test soup administration, snacks and water (ad lib) will be provided and subjects will be instructed to eat as much as or as little as they desire, followed by completing the satiety motivational questionnaire. At 3 h 15 min and at 4 h, subjects will complete the satiety motivational questionnaire.

Test periods 2 and 3 will be scheduled between 3-14 days after completing test period visit 1: all procedures are identical on each test period visit with the exception of the test treatment soup consumed by subjects.
Study Started
Jul 31
2010
Primary Completion
Jan 31
2011
Study Completion
Jan 31
2011
Last Update
Feb 11
2013
Estimate

Dietary Supplement Soup 1

Consommé soup with Monosodium L-Glutamate (MSG)

Dietary Supplement Soup 2

Consommé soup with Monosodium L-Glutamate (MSG) and Nucleic Acid (IMP)

Dietary Supplement Soup 3

Placebo soup with no Monosodium L-Glutamate (MSG) or Nucleic Acid (IMP)

Soup 1 Active Comparator

Consommé soup with Monosodium L-Glutamate (MSG)

Soup 2 Active Comparator

Consommé soup with Monosodium L-Glutamate (MSG) and Nucleic Acid (IMP)

Soup 3 Placebo Comparator

Placebo soup with no Monosodium L-Glutamate (MSG) or Nucleic Acid (IMP)

Criteria 

Inclusion Criteria:

Healthy Female, 30 to 45 yrs old
Non-smoker
Non-heavy Drinker
BMI between 18.5 and 25.0 inclusive at the screening visit

Exclusion Criteria:

History or presence of any serious and/or chronic medical or clinical disease, including renal disease, hepatic (biliary) disease, uncontrolled hypertension or uncontrolled thyroid disease, surgical conditions, cardiovascular disease other than mild hypertension or dyslipidemias, myocardial infarction, or other conditions that in the opinion of the investigator may increase the risk of participation or compromise/confound the study results
History or diagnosis of type 1 or 2 diabetes mellitus or other uncontrolled endocrine disease
Dysgeusia
Any history of gastrointestinal disease or currently on treatment for a digestive disease
Eating disorder or abnormal eating habits
Undergone a recent significant weight change (gain or loss)
Participating on a weight-loss program within the past 6 months prior to entry into the study
Taking any medications for the alimentary system
Allergy or sensitivity to foods or food additives
History of using habitual drugs and/or alcohol abuse within the past year
Psychosis and/or suffering from any other condition(s) which might render the individual unable to comply with the protocol or place subjects at increased risk at the discretion of the PI
Used any investigational drug or product within the 1 month prior to the screening visit
On special diet such as vegetarian
Dislike the preloading soup and/or the provided lunch and/or study snacks
Currently breast feeding and/or pregnant in the past 6 months
No Results Posted