Title
Changes in Acid Base Status During High Salt Intake
Phase
N/ALead Sponsor
DLR German Aerospace CenterStudy Type
InterventionalStatus
Completed No Results PostedIndication/Condition
Low Grade Metabolic AcidosisIntervention/Treatment
sodium bicarbonate ...Study Participants
8The study aimed to examine the effects of an alkalinisation of a NaCl (sodium chloride, salt)-rich diet on acid base status, bone metabolism, protein turnover and other influenced physiological systems. Due to increased urinary calcium excretion and bone resorption a high NaCl-intake is considered as a risk factor for osteoporosis. On the contrary an alkaline diet is known to have a beneficial influence on bone metabolism. Therefore the investigators hypothesized that an alkaline diet can reduce NaCl-induced bone resorption.
8 healthy male volunteers took part in a stationary study carried out in the metabolic ward of the German Aerospace Center. The study consisted of 2 campaigns, each lasting 16 days. Both campaigns were divided into 5 days of adaptation, 10 days of intervention and 1.5 days of stationary recovery. During the intervention period the volunteers diet was NaCl-rich (7.7 mmol Na/kg body weight/day) and supplemented in one campaign by 90 mmol potassium bicarbonate (KHCO3) in a randomized cross-over design. The other campaign served as control.
Bone metabolism was studied by bone formation markers in the fasting morning blood and 24h-urinary bone resorption markers. Acid base status was assessed by blood gas analyses in the fasted and the postprandial state as well as urinary markers. Protein turnover was studied with stable isotopes. Further physiological systems like energy metabolism and the cardiovascular system are also under investigation.
7.7 mmol Na/kgBW/d + 90 mmol KHCO3
7.7 mmol Na/kgBW/d
Inclusion Criteria: healthy males 19 - 35 years 65 - 85kg 170 - 190 cm successfully completed psychological and medical screening Exclusion Criteria: athletes smoking drug- or alcohol abuse hyperlipidemia renal diseases obesity anemia bone diseases diabetes rheumatism blood donation within three month prior to study start participation in another clinical investigation three month prior to study start
